ArticleRheumatology international2013
The factors considered as trigger for the attacks in patients with familial Mediterranean fever.
Article in Rheumatology international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Multicentre cohort study on the course of paediatric familial Mediterranean fever in the aftermath of the 2023 earthquake.BMJ paediatrics open · 2026Article
- Premenstrual syndrome and inflammatory activity in adolescent familial Mediterranean fever.Rheumatology (Oxford, England) · 2026Article
- Mediterranean diet adherence in pediatric familial Mediterranean fever: clinical and inflammatory correlates.Frontiers in pediatrics · 2026Article
- Anesthetic Management of a Dental Patient With Familial Mediterranean Fever.Anesthesia progress · 2025Article
- What do patients do during a familial Mediterranean fever attack? Their strategies and associated factors.Internal and emergency medicine · 2025Article
- The Impact of Menopause on Autoimmune and Rheumatic Diseases.Clinical reviews in allergy & immunology · 2025Review
- A treatment algorithm for familial Mediterranean fever patients with menstruation-associated attacks.Rheumatology (Oxford, England) · 2025Article
- Investigation of dysmenorrhea in adolescent girls with familial Mediterranean fever: a comparative study with healthy controls.European journal of pediatrics · 2025Article
- Familial Mediterranean Fever (FMF): Emerging Concepts in Diagnosis, Pain Management, and Novel Treatment Options: A Narrative Review.Current pain and headache reports · 2025Review
- Factors triggering familial mediterranean fever attacks, do they really exist?Internal and emergency medicine · 2024Article
- Do we consider enough the presence of triggering factors in the evaluation of patients with FMF? Triggering factors are highly prevalent in colchicine-resistant FMF patients.Internal and emergency medicine · 2024Article
- Familial Mediterranean fever in Romania: a case report and literature review.Frontiers in pediatrics · 2024Review
- An Update on Familial Mediterranean Fever.International journal of molecular sciences · 2023Review
- Increase in pediatric recurrent fever evaluations during the first year of the COVID-19 pandemic in North America.Frontiers in pediatrics · 2023Article
- Seasonal residual activity in adult familial Mediterranean fever: a longitudinal observational study.Rheumatology international · 2022Observational
- PFAPA flares observed during COVID outbreak: can emotional stress trigger PFAPA attacks? A multicenter cohort study.Pediatric rheumatology online journal · 2022Article
- The Preferential Use of Anakinra in Various Settings of FMF: A Review Applied to an Updated Treatment-Related Perspective of the Disease.International journal of molecular sciences · 2022Review
- Clinical and genetic characterization of familial Mediterranean fever among a cohort of Egyptian patients.Przeglad gastroenterologiczny · 2022Article
- A Hypothesis Regarding Neurosecretory Inhibition of Stress Mediators by Colchicine in Preventing Stress-Induced Familial Mediterranean Fever Attacks.Frontiers in immunology · 2022Article
- Work productivity impairment in patients with familial Mediterranean fever and effects of interleukin-1 antagonists.Clinical rheumatology · 2021Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the inflammatory cascade of familial Mediterranean fever (FMF) is partially understood, triggering factors of those attacks has not been studied well. It is supposed that physical stresses such as cold exposure, tiredness and emotional stresses could provoke attacks. This study is aimed to survey the factors regarded as triggering the attacks in patients with FMF and their relationship with MEFV gene mutations. Clinical findings and genetic mutations (consist of M694V, M694I, M680I, V726A, E148Q) of patients were recorded. Patients were questioned about cold exposure, emotional stress, tiredness, long-lasting standing, long-duration travel, starvation, high intake of food, trauma, and infection as triggering factors for the attacks with both serositis and musculoskeletal pain. The study is comprised of 275 FMF patients (male/female: 177/98). The most common triggering factors for the attacks with serositis were cold exposure (59.3 %), emotional stress (49.8 %), tiredness (40.0 %) and menstruation (33.7 % in females). Long-lasting standing (78.8 %), long-duration travel (64.1 %) and tiredness (47.8 %) were the triggering factors for the attacks with musculoskeletal symptoms. The relationships between MEFV mutations and triggering factors were found as M694V allele with starvation, E148Q allele with high intake of food and V726A allele with long-duration travel. The attacks with serositis seem to be triggered by those factors to which whole body exposed, whereas the attacks with musculoskeletal complaints seem to be triggered by those factors to which regional or local part of body exposed. Since the number of alleles was small, a clear conclusion for a relationship between a particular gene variant and a specific trigger was not made.
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