Evidence map›Paper›PMID 22814587›Full record

ReviewNature reviews. Neuroscience2012

Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease.

Irfan A Qureshi, Mark F Mehler

Abstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 326 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
326citing papers in PubMed, 1 pooled it
23.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

326 citing papers in PubMed, 1 synthesis or guideline pooled it, 562 citations in OpenAlex.

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266 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Irfan A QureshiRoslyn and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, New York, New York 10461, USA. irfan@jhu.edu
Mark F Mehler
Albert Einstein College of Medicine · US

Funding

Support for MRRC - Biometry CoreP30HD001799 · NICHD · YESHIVA UNIVERSITY · PI FABER, DONALD S · 1985 to 2005
$6.5M
Translational Neuroimaging CoreP30HD071593 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WALKLEY, STEVEN UPSHAW · 2011 to 2015
$5.6M
Mechanisms Regulating Astroglial Lineage DevelopmentR01MH066290 · NIMH · YESHIVA UNIVERSITY · PI MEHLER, MARK F · 2002 to 2006
$1.8M
Neurodegenerative Diseases: A New Class of Primary Developmental Disorders?R01NS071571 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MEHLER, MARK F · 2010 to 2013
$1.3M
NICHD NIH HHS HD071593NICHD NIH HHS P30 HD001799NICHD NIH HHS P30 HD071593NIMH NIH HHS MH66290NIMH NIH HHS R01 MH066290NINDS NIH HHS NS071571NINDS NIH HHS R01 NS071571
6 · The paper itself

Abstract

Novel classes of small and long non-coding RNAs (ncRNAs) are being characterized at a rapid pace, driven by recent paradigm shifts in our understanding of genomic architecture, regulation and transcriptional output, as well as by innovations in sequencing technologies and computational and systems biology. These ncRNAs can interact with DNA, RNA and protein molecules; engage in diverse structural, functional and regulatory activities; and have roles in nuclear organization and transcriptional, post-transcriptional and epigenetic processes. This expanding inventory of ncRNAs is implicated in mediating a broad spectrum of processes including brain evolution, development, synaptic plasticity and disease pathogenesis.

Indexed as

Biological EvolutionAnimalsBrainBrain DiseasesHumansNeuronal PlasticityRNA, UntranslatedRNA, Untranslated

Identifiers

PMID22814587
PMCPMC3478095
OpenAlexW1981640964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.