Evidence map›Paper›PMID 22814458›Full record

ArticleJournal of clinical microbiology2012

Targeting both rs12979860 and rs8099917 polymorphisms with a single-tube high-resolution melting assay for IL28b genotyping.

Kok Siong Poon, Sherry Sze Yee Ho, Julian Wei-Tze Tang, Cui Wen Chua, Lily Chiu, Evelyn Siew-Chuan Koay

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kok Siong PoonMolecular Diagnosis Centre, Department of Laboratory Medicine, National University Health System, Singapore.
Sherry Sze Yee Ho
Julian Wei-Tze Tang
Cui Wen Chua
Lily Chiu
Evelyn Siew-Chuan Koay
National University Health System · SGUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A rapid, duplex, high-resolution melting interleukin-28B gene (IL28B) genotyping assay, targeting both rs12979860 and rs8099917 polymorphisms, was developed and validated using 30 DNA samples from healthy volunteers. A linkage study on 300 healthy Singaporeans showed variable haplotypes. When the assay was applied to plasma DNA from 50 hepatitis C virus genotype-1 (HCV-1)-infected patients, five compound heterozygous types were detected.

Indexed as

Polymorphism, Single NucleotideClinical Laboratory TechniquesGenotypeHaplotypesHepacivirusHepatitis CHumansInterferon LambdaInterferonsInterleukinsMolecular Diagnostic TechniquesNucleic Acid DenaturationSingaporeTransition TemperatureInterferon Lambdainterferon-lambda, humanInterferonsInterleukins

Identifiers

PMID22814458
PMCPMC3457426
OpenAlexW2143993063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.