ArticleDementia and geriatric cognitive disorders2012
Leptin and cognition.
Article in Dementia and geriatric cognitive disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cognitive Function during and after Pregnancy and One-Year Postpartum in Type 1 Diabetes: A Longitudinal Study.Nutrients · 2024Article
- Positive Association between Preserved C-Peptide and Cognitive Function in Pregnant Women with Type-1 Diabetes.Biomedicines · 2022Article
- The effects of a 6-week controlled, hypocaloric ketogenic diet, with and without exogenous ketone salts, on cognitive performance and mood states in overweight and obese adults.Frontiers in neuroscience · 2022Article
- Anatomical Brain Changes and Cognitive Abilities in Patients with Obstructive Sleep Apnea Syndrome and Nonalcoholic Fatty Liver Disease.Canadian journal of gastroenterology & hepatology · 2021Article
- Neurocognitive Inhibitory Control Ability Performance and Correlations with Biochemical Markers in Obese Women.International journal of environmental research and public health · 2020Article
- Associations of Bone Turnover Markers with Cognitive Function in Patients Undergoing Hemodialysis.Disease markers · 2020Article
- Association Between Leptin, Cognition, and Structural Brain Measures Among "Early" Middle-Aged Adults: Results from the Framingham Heart Study Third Generation Cohort.Journal of Alzheimer's disease : JAD · 2020Article
- White matter microstructure and cognitive decline in metabolic syndrome: a review of diffusion tensor imaging.Metabolism: clinical and experimental · 2018Review
- Ionizing Radiation-Induced Immune and Inflammatory Reactions in the Brain.Frontiers in immunology · 2017Review
- Adiponectin Receptors Are Less Sensitive to Stress in a Transgenic Mouse Model of Alzheimer's Disease.Frontiers in neuroscience · 2017Article
- Plasma leptin levels are not predictive of dementia in patients with mild cognitive impairment.Age and ageing · 2015Article
- Association between Plasma Leptin and Estrogen in Female Patients of Amnestic Mild Cognitive Impairment.Disease markers · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLeptin has been reported to have positive effects on cognition but has not been studied in a population-based sample or stratified by race or gender.
methodsLeptin and fat mass were measured in 2,731 subjects, including 50% African Americans. Eight years later, subjects were administered the Montreal Cognitive Assessment (MoCA). Demographic factors and baseline measures, including a deficiency in leptin or levels in excess of what was predicted by fat, were investigated to see which predicted cognitive performance.
resultsThere was a statistical trend for lower leptin levels to be associated with higher cognitive scores. Once stratified by race and gender, excessive leptin was associated with lower MoCA total scores and delayed recall domain score for black men, but white men demonstrated a reverse relationship.
conclusionExcess leptin appears to have differential effects on delayed recall in black and white men.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.