ArticleAnnals of the New York Academy of Sciences2012
The ethics of research on deep brain stimulation for depression: decisional capacity and therapeutic misconception.
Article in Annals of the New York Academy of Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Barriers and facilitators to implementing deep brain stimulation for psychiatric disorders: a systematic review.Translational psychiatry · 2026Pooled it
- Informed consent competency assessment for brain-computer interface clinical research and application in psychiatric disorders: A systematic review.World journal of psychiatry · 2025Article
- Qualitative Analysis of Decision to Pursue Electrical Brain Stimulation by Patients With Drug-Resistant Epilepsy and Their Caregivers.Neurology. Clinical practice · 2024Article
- Article
- "Nothing to Lose, Absolutely Everything to Gain": Patient and Caregiver Expectations and Subjective Outcomes of Deep Brain Stimulation for Treatment-Resistant Depression.Frontiers in human neuroscience · 2021Article
- Informed consent, therapeutic misconception, and clinical trials for Alzheimer's disease.International journal of geriatric psychiatry · 2020Article
- How Neuroscience Is Informing Treatments: Ethical Issues.Focus (American Psychiatric Publishing) · 2019Article
- Deep Brain Stimulation in Psychiatry: Mechanisms, Models, and Next-Generation Therapies.The Psychiatric clinics of North America · 2018Review
- Should DBS for Psychiatric Disorders be Considered a Form of Psychosurgery? Ethical and Legal Considerations.Science and engineering ethics · 2018Article
- Informed Consent Decision-Making in Deep Brain Stimulation.Brain sciences · 2018Review
- The Ethics of Clinical Trials Research in Severe Mood Disorders.Bioethics · 2017Article
- Deep Brain Stimulation in Anorexia Nervosa: Hope for the Hopeless or Exploitation of the Vulnerable? The Oxford Neuroethics Gold Standard Framework.Frontiers in psychiatry · 2017Article
- Autonomy in Depressive Patients Undergoing DBS-Treatment: Informed Consent, Freedom of Will and DBS' Potential to Restore It.Frontiers in integrative neuroscience · 2017Article
- Informed Consent in Implantable BCI Research: Identifying Risks and Exploring Meaning.Science and engineering ethics · 2016Article
- Therapeutic Misconception in Psychiatry Research: A Systematic Review.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2016Article
- Is Conduct of Research in Electroconvulsive Therapy Ethical?Journal of psychology, neuropsychiatric disorders and brain stimulation · 2016Article
- The ethics of neuromodulation for anorexia nervosa: a focus on rTMS.Journal of eating disorders · 2014Article
- Deep brain stimulation in the treatment of depression.Dialogues in clinical neuroscience · 2014Review
- Before it is too late: professional responsibilities in late-onset Alzheimer's research and pre-symptomatic prediction.Frontiers in human neuroscience · 2014Article
- Deep brain stimulation (DBS) at the interface of neurology and psychiatry.The Journal of clinical investigation · 2013Review
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 1 country.
Funding
Abstract
Research on deep brain stimulation (DBS) for treatment-resistant depression appears promising, but concerns have been raised about the decisional capacity of severely depressed patients and their potential misconceptions about the research. We assessed 31 DBS research participants with the MacArthur Competence Assessment Tool for Clinical Research (MacCAT-CR), a well-validated capacity measure, and with a scale to measure therapeutic misconception, which occurs when subjects do not recognize key differences between treatment and clinical research. Correlations with baseline depressive symptoms were explored. Subjects' performance on the MacCAT-CR was excellent, but therapeutic misconception was still apparent. A trend toward significance was found in the correlation between baseline depression ratings and total therapeutic misconception score. Responses to open-ended prompts revealed both reassuring and concerning statements related to expectations of risk, benefit, and individualization. Even severely depressed patients did not manifest impairments in their capacity to consent to DBS research. Therapeutic misconception, however, remained prevalent.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.