ArticleFEMS microbiology letters2012
Iron acquisition in the marine actinomycete genus Salinispora is controlled by the desferrioxamine family of siderophores.
Article in FEMS microbiology letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Homo-/Heterodimeric Substrates Bias the Type and Multiplicity of Hydroxamic Acid Chelators Assembled by a NIS Synthetase DesD.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Contrasting bioavailability of enterobactin- and ferrichrome-bound iron to SAR11 and other marine heterotrophs.ISME communications · 2026Article
- Strategies Used for the Discovery of New Microbial Metabolites with Antibiotic Activity.Molecules (Basel, Switzerland) · 2025Review
- Novel XAD-LC/MS-FBMN-IMS Strategy for ScreeningAnalytical chemistry · 2025Article
- An elastic siderophore synthetase and rubbery substrates assemble multimeric linear and macrocyclic hydroxamic acid metal chelators.Chemical science · 2025Article
- Intermediates and shunt products of massiliachelin biosynthesis inBeilstein journal of organic chemistry · 2023Article
- Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica.Microbial biotechnology · 2021Article
- Comparative Genomics ofFrontiers in microbiology · 2020Article
- Reduction-dependent siderophore assimilation in a model pennate diatom.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The role of inter-species interactions in Salinispora specialized metabolism.Microbiology (Reading, England) · 2018Article
- Diversification of Secondary Metabolite Biosynthetic Gene Clusters Coincides with Lineage Divergence in Streptomyces.Antibiotics (Basel, Switzerland) · 2018Article
- Function-related replacement of bacterial siderophore pathways.The ISME journal · 2018Article
- Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Genomic insights into specialized metabolism in the marine actinomycete Salinispora.Environmental microbiology · 2017Article
- Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols.Journal of natural products · 2017Article
- Siderophore-based microbial adaptations to iron scarcity across the eastern Pacific Ocean.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Competitive strategies differentiate closely related species of marine actinobacteria.The ISME journal · 2016Article
- Accurate mass MS/MS/MS analysis of siderophores ferrioxamine B and E1 by collision-induced dissociation electrospray mass spectrometry.Journal of the American Society for Mass Spectrometry · 2015Article
- The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery.Natural product reports · 2015Review
- Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species.Chemistry & biology · 2015Article
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5 authors.
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Abstract
Many bacteria produce siderophores for sequestration of growth-essential iron. Analysis of the Salinispora genomes suggests that these marine actinomycetes support multiple hydroxamate- and phenolate-type siderophore pathways. We isolated and characterized desferrioxamines (DFOs) B and E from all three recognized Salinispora species and linked their biosyntheses in S. tropica CNB-440 and S. arenicola CNS-205 to the des locus through PCR-directed mutagenesis. Gene inactivation of the predicted iron-chelator biosynthetic loci sid2-4 did not abolish siderophore chemistry. Additionally, these pathways could not restore the native growth characteristics of the des mutants in iron-limited media, although differential iron-dependent regulation was observed for the yersiniabactin-like sid2 pathway. Consequently, this study indicates that DFOs are the primary siderophores in laboratory cultures of Salinispora.
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