ArticleJournal of periodontal research2013
Antibacterial effects of blackberry extract target periodontopathogens.
Article in Journal of periodontal research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Effect of a mouthrinse containing rice peptide CL(14-25) on early dental plaque regrowth: a randomized crossover pilot study.BMC research notes · 2015Trial
- Goldenberry (Physalis peruviana L.) juice inhibits foodborne pathogens while promoting probiotic bacterial growth.Scientific reports · 2026Article
- Mapping 60 Years of Discovery: An AI-Driven Bibliometric and Altmetric Analysis of the Journal of Periodontal Research.Journal of periodontal research · 2025Article
- Herbal remedies for oral and dental health: a comprehensive review of their multifaceted mechanisms including antimicrobial, anti-inflammatory, and antioxidant pathways.Inflammopharmacology · 2025Review
- Article
- Impact of oral pathogens on inflammatory mediator expression in oral cells.Bioinformation · 2025Article
- The relationship of dietary flavonoids and periodontitis in US population: a cross-sectional NHANES analysis.Clinical oral investigations · 2024Article
- Biological Properties of Recently Described Wild BrambleFoods (Basel, Switzerland) · 2024Article
- Phytochemicals Determination, and Antioxidant, Antimicrobial, Anti-Inflammatory and Anticancer Activities of Blackberry Fruits.Foods (Basel, Switzerland) · 2023Article
- Therapeutic Potential of Flavonoids and Tannins in Management of Oral Infectious Diseases-A Review.Molecules (Basel, Switzerland) · 2022Review
- Selective Inhibition of the Periodontal PathogenJournal of medicinal chemistry · 2022Article
- Anthocyanin Addition to Kefir: Metagenomic Analysis of Microbial Community Structure.Current microbiology · 2022Article
- Antiviral and Antibacterial Effect of Honey Enriched withMolecules (Basel, Switzerland) · 2022Article
- Can Plant Materials Be Valuable in the Treatment of Periodontal Diseases? Practical Review.Pharmaceutics · 2021Review
- Blackberry Leaves as New Functional Food? Screening Antioxidant, Anti-Inflammatory and Microbiological Activities in Correlation with Phytochemical Analysis.Antioxidants (Basel, Switzerland) · 2021Article
- Oral commensal bacteria differentially modulate epithelial cell death.Archives of oral biology · 2020Article
- Antimicrobial Activity ofInternational journal of microbiology · 2018Article
- Effects of azithromycin, metronidazole, amoxicillin, and metronidazole plus amoxicillin on an in vitro polymicrobial subgingival biofilm model.Antimicrobial agents and chemotherapy · 2015Article
- Retention of polyphenolic species in spray-dried blackberry extract using mannitol as a thermoprotectant.Journal of medicinal food · 2014Article
- Porphyromonas gingivalis: keeping the pathos out of the biont.Journal of oral microbiology · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND AND
objectiveAntimicrobial agents provide valuable adjunctive therapy for the prevention and the control of oral diseases. Limitations in their prolonged use have stimulated the search for new, naturally occurring agents with more specific activity and fewer adverse effects. Here we sought to determine the antibacterial properties of blackberry extract (BBE) in vitro against oral bacterial commensals and periodontopathogens. MATERIAL AND
methodsThe effects of whole and fractionated BBE on the metabolism of 10 different oral bacteria were evaluated using the colorimetric water-soluble tetrazolium-1 assay. The bactericidal effects of whole BBE against Fusobacterium nucleatum were determined by quantitating the numbers of colony-forming units (CFUs). Cytotoxicity was determined in oral epithelial (OKF6) cells.
resultsBBE at 350-1400 μg/mL reduced the metabolic activity of Porphyromonas gingivalis, F. nucleatum and Streptococcus mutans. The reduced metabolic activity observed for F. nucleatum corresponded to a reduction in the numbers of CFUs following exposure to BBE for as little as 1 h, indicative of its bactericidal properties. An anthocyanin-enriched fraction of BBE reduced the metabolic activity of F. nucleatum, but not of P. gingivalis or S. mutans, suggesting the contribution of species-specific agents in the whole BBE. Oral epithelial cell viability was not reduced following exposure to whole BBE (2.24-1400 μg/mL) for ≤ 6 h.
conclusionBBE alters the metabolic activity of oral periodontopathogens while demonstrating a minimal effect on commensals. The specific antibacterial properties of BBE shown in this study, along with its previously demonstrated anti-inflammatory and antiviral properties, make this natural extract a promising target as an adjunct for prevention and/or complementary therapy of periodontal infections.
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