ArticleJournal of gastrointestinal oncology2011
A new experimental model to allow use of clinical-scale endoscopes in small-animal tumor models.
Article in Journal of gastrointestinal oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Endoscopic innovation through animal experiments: a new in-vitro platform.Journal of gastrointestinal oncology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe evaluation of novel endoscopes may require testing in experimental tumor models, particularly when employing new biomarkers. Tumor models, however, exist almost exclusively in small animals. Therefore, we aimed to develop an experimental setting that allows the use of clinical-scale endoscopes in small animals.
methodsIn our approach, the proximal large bowel with intact blood supply is exposed on a movable and height-adjustable table. The endoscope's tip may be inserted into the bowel; the dark environment of the bowel lumen in vivo is simulated by mounting a light-tight curtain around the endoscope. Proof-of-principle experiments were done in Wag/Rij rats following cecal injection of the cell line R1H.
resultsUsing high-definition television white-light endoscopy, narrow-band and autofluorescence imaging, and miniprobe-based confocal laser microscopy (CLM) marked differences were observed between normal mucosa and tumors. Depending on the techniques, mean examination times ranged from 3 to 10 minutes. Even after 90 minutes the colon displayed an intact blood supply, imaged by Evans blue injection and by CLM.
conclusionThese experiments demonstrate that our model allows in vivo examination of small-animals by clinical-scale endoscopes. Therefore, it may be useful for evaluation, at various stages of GI carcinogenesis, of both new biomarkers and endoscopic technologies.
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