ArticleJournal of biomedicine & biotechnology2012
Treatment with aqueous extract from Croton cajucara Benth reduces hepatic oxidative stress in streptozotocin-diabetic rats.
Article in Journal of biomedicine & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Secondary Metabolites fromMetabolites · 2025Review
- Diabetes-Related Mechanisms of Action Involved in the Therapeutic Effect ofPlants (Basel, Switzerland) · 2023Review
- Contributions from Mexican Flora for the Treatment of Diabetes Mellitus: Molecules ofMolecules (Basel, Switzerland) · 2021Review
- In Vitro Cytotoxicity and Anti-HIV Activity of Crude Extracts ofJournal of experimental pharmacology · 2021Article
- Effect of Extract and Ellagic Acid fromAntioxidants (Basel, Switzerland) · 2018Article
- Polyploidy Analysis and Attenuation of Oxidative Stress in Hepatic Tissue of STZ-Induced Diabetic Rats Treated with an Aqueous Extract of Vochysia rufa.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Effect of Boswellia serrata supplementation on blood lipid, hepatic enzymes and fructosamine levels in type2 diabetic patients.Journal of diabetes and metabolic disorders · 2014Article
- Progesterone and cilostazol protect mice pancreatic islets from oxidative stress induced by hydrogen peroxide.Iranian journal of pharmaceutical research : IJPR · 2014Article
- Antimicrobial and selected in vitro enzyme inhibitory effects of leaf extracts, flavonols and indole alkaloids isolated from Croton menyharthii.Molecules (Basel, Switzerland) · 2013Article
- Therapeutic potential of some plant extracts used in Turkish traditional medicine on streptozocin-induced type 1 diabetes mellitus in rats.The Journal of membrane biology · 2013Article
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9 authors.
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Abstract
Croton cajucara Benth is a plant found in Amazonia, Brazil and the bark and leaf infusion of this plant have been popularly used to treat diabetes and hepatic disorders. The present study was designed to evaluate the oxidative stress as well as the therapeutic effect of Croton cajucara Benth (1.5 mL of the C. cajucara extract i.g.) in rats with streptozotocin-induced diabetes. Croton cajucara Benth was tested as an aqueous extract for its phytochemical composition, and its antioxidant activity in vitro was also evaluated. Lipid peroxidation and superoxide dismutase, catalase, and glutathione reductase activities were measured in the hepatic tissue, as well as the presence activation of p65 (NF-κB), through western blot. Phytochemical screening of Croton cajucara Benth detected the presence of flavonoids, coumarins and alkaloids. The extract exhibited a significant antioxidant activity in the DPPH-scavenging and the hypoxanthine/xanthine oxidase assays. Liver lipid peroxidation increased in diabetic animals followed by a reduction in the Croton-cajucara-Benth-treated group. There was activation of p65 nuclear expression in the diabetic animals, which was attenuated in the animals receiving the Croton cajucara Benth aqueous extract. The liver tissue in diabetic rats showed oxidative alterations related to the streptozotocin treatment. In conclusion the Croton cajucara Benth aqueus extract treatment effectively reduced the oxidative stress and contributed to tissue recovery.
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