ArticleJournal of clinical laboratory analysis2012
Prolidase and oxidative stress in chronic hepatitis C.
Article in Journal of clinical laboratory analysis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Effect of Silymarin as an Adjunct Therapy in Combination with Sofosbuvir and Ribavirin in Hepatitis C Patients: A Miniature Clinical Trial.Oxidative medicine and cellular longevity · 2022Trial
- Enhanced Efficacy of Direct-Acting Antivirals in Hepatitis C Patients by Coadministration of Black Cumin and Ascorbate as Antioxidant Adjuvants.Oxidative medicine and cellular longevity · 2020Trial
- PROLIDASE: A Review from Discovery to its Role in Health and Disease.Frontiers in molecular biosciences · 2021Review
- Serum prolidase level in patients with brucellosis and its possible relationship with pathogenesis of the disease: a prospective observational studyTurkish journal of medical sciences · 2019Observational
- Evaluation of serum prolidase activity and oxidative stress markers in men with BPH and prostate cancer.BMC urology · 2017Article
- The relationships among the levels of oxidative and antioxidative parameters, FEV1 and prolidase activity in COPD.Redox report : communications in free radical research · 2017Article
- Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma.World journal of gastroenterology · 2015Article
- Oxidative stress response in patients infected by diverse hepatitis C virus genotypes.Hepatitis monthly · 2015Article
- Serum prolidase activity and oxidant-antioxidant status in children with chronic hepatitis B virus infection.Italian journal of pediatrics · 2014Article
- Role of oxidative stress in infectious diseases. A review.Folia microbiologica · 2013Review
- Does prolidase indicate worsening of hepatitis B infection?Journal of clinical laboratory analysis · 2013Article
- Mitochondrial dysfunctions and altered metals homeostasis: new weapons to counteract HCV-related oxidative stress.Oxidative medicine and cellular longevity · 2013Review
- Evaluation of serum prolidase enzyme activity and oxidative stress in patients with tinnitus.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatitis C infection represents a common healthcare issue worldwide. The present trial was designed to investigate the role of prolidase, an enzyme that is significantly involved in the biosynthesis of collagen, and of the oxidative stress that is considered to be involved in the pathogenesis of various diseases, in the chronic hepatitis C infection. The trial was performed to assess the serum prolidase enzyme level and the oxidative-antioxidative status and to determine the relation between the serum prolidase activity and the oxidative stress parameters.
methodsA total of 95 individuals, including 55 patients with chronic hepatitis C infection (CHC) and 40 healthy adults, were enrolled in the trial. The values for prolidase, the total antioxidant status (TAS), the total oxidative stress (TOS), the oxidative stress index (OSI), sulfhydryl (SH), lipid peroxidation LOOH, catalase (CAT), and ceruloplasmin were measured and compared between the patient groups.
resultsThe prolidase, TOS, LOOH, CAT, and the OSI values were higher in the chronic hepatitis C group compared to the control group (P < 0.001). The TAS, SH, and ceruloplasmin levels were lower in the CHC group relative to the control group (P < 0.001).
conclusionWe suppose that the values of prolidase and the oxidative stress are increased while the antioxidant levels are decreased in CHC. As a result, prolidase and the oxidative stress seem to be related with the progression of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.