ArticleMolecular and cellular biochemistry2012
Implication of BBM lipid composition and fluidity in mitigated alkaline phosphatase activity in renal cell carcinoma.
Article in Molecular and cellular biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Alleviating Clostridium perfringens-Induced Gut Lesionsin Broiler Chickens by Orally Administered Bovine Intestinal Alkaline Phosphatase.Probiotics and antimicrobial proteins · 2026Article
- Structural Changes in Pellets of Calcium Phosphate Ester Salts after Exposure to Simulated Body Fluid with the Addition of Alkaline Phosphatase.ACS omega · 2025Article
- Insight into the effects of Omega-3 fatty acids on gut microbiota: impact of a balanced tissue Omega-6/Omega-3 ratio.Frontiers in nutrition · 2025Review
- Plasma Levels of Omega-3 and Omega-6 Derived Oxylipins Are Associated with Fecal Microbiota Composition in Young Adults.Nutrients · 2022Article
- Potent Alkaline Phosphatase Inhibitors, Pyrazolo-Oxothiazolidines: Synthesis, Biological Evaluation, Molecular Docking, and Kinetic Studies.International journal of molecular sciences · 2022Article
- Intestinal Alkaline Phosphatase: A Review of This Enzyme Role in the Intestinal Barrier Function.Microorganisms · 2022Review
- Potential of Omega-3 Polyunsaturated Fatty Acids in Managing Chemotherapy- or Radiotherapy-Related Intestinal Microbial Dysbiosis.Advances in nutrition (Bethesda, Md.) · 2019Review
- A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia.Scientific reports · 2015Article
- Article
- Alkaline phosphatase: an overview.Indian journal of clinical biochemistry : IJCB · 2014Review
- Metallothionein gene expression in renal cell carcinoma.Indian journal of urology : IJU : journal of the Urological Society of India · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous study has documented reduced alkaline phosphatase (ALP) activity in brush border membrane (BBM) isolated from renal cell carcinoma (RCC). Diminished activity of ALP is associated with alteration in both increased K(m) as well as decreased V(max) of enzyme suggests that there may be a change in the conformation of enzyme as well as decreased number of ALP active molecules. The present study was conducted to find out any role of BBM lipid composition and its fluidity in diminished activity of alkaline phosphatase in renal cell carcinoma. Total phospholipids and glycolipids were significantly augmented in BBM from RCC as compared to control. Fractional analysis of total phospholipids revealed significantly increased phosphatidylethanolamine. Decreased fractions of sphingomyelin and phosphatidylinositol were observed. Cholesterol-to-total phospholipid molar ratios in tumor BBM was a significantly lower in tumor BBM. A significant reduction in polarization and microviscosity was found in BBM from RCC. Therefore, we conclude that alteration in membrane lipid composition and fluidity may play a substantial role in reduced activity of ALP in RCC.
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