ArticleEuropean journal of nutrition2013
The polyphenol-rich extracts from black chokeberry and grape seeds impair changes in the platelet adhesion and aggregation induced by a model of hyperhomocysteinemia.
Article in European journal of nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 30 citations in OpenAlex.
- Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial.EBioMedicine · 2021Trial
- Effects of antioxidant supplementation on oxidative stress balance in young footballers- a randomized double-blind trial.Journal of the International Society of Sports Nutrition · 2021Trial
- Prebiotic-like Effects of Proanthocyanidin-Rich Aronia Extract Supplementation on Gut Microbiota Composition and Function in the Twin-M-SHIMEPharmaceuticals (Basel, Switzerland) · 2025Article
- Contribution of Physical Activity to the Oxidative and Antioxidant Potential in 60-65-Year-Old Seniors.Antioxidants (Basel, Switzerland) · 2023Article
- The Efficacy of Black Chokeberry Fruits against Cardiovascular Diseases.International journal of molecular sciences · 2021Review
- The Protective Effect of Anthocyanins Extracted fromMediators of inflammation · 2021Article
- Article
- Molecular Mechanisms ofMolecules (Basel, Switzerland) · 2019Article
- Evaluation of anthocyanins in Aronia melanocarpa/BSA binding by spectroscopic studies.AMB Express · 2018Article
- Berry Phenolic Antioxidants - Implications for Human Health?Frontiers in pharmacology · 2018Review
- Dietary Supplements with Antiplatelet Activity: A Solution for Everyone?Advances in nutrition (Bethesda, Md.) · 2018Review
- Fruits for Prevention and Treatment of Cardiovascular Diseases.Nutrients · 2017Review
- Berberine activates peroxisome proliferator-activated receptor gamma to increase atherosclerotic plaque stability in ApoeJournal of diabetes investigation · 2016Article
- Extract of Aronia melanocarpa-modified hemostasis: in vitro studies.European journal of nutrition · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThe mechanism action of the polyphenol-rich extracts from berries of Aronia melanocarpa (black chokeberry) and from grape seeds in the defence against homocysteine (Hcy) and its derivatives action in blood platelets is still unknown. In this study, the influence of the aronia extract and grape seeds extract (GSE) on the platelet adhesion to collagen and fibrinogen and the platelet aggregation during a model of hyperhomocysteinemia was investigated. The aim of our study in vitro was also to investigate superoxide anion radicals (O₂⁻•) production after incubation of platelets with Hcy, HTL and the aronia extract and GSE during a model of hyperhomocysteinemia (induced by reduced form of homocysteine at final dose of 100 μM) and the most reactive form of Hcy--its cyclic thioester, homocysteine thiolactone (HTL, 1 μM). Moreover, the additional aim of our study was also to establish and compare the influence of the aronia extract, GSE and resveratrol (3,4',5-trihydroxystilben), a phenolic compound, which has been supposed to be beneficial for the prevention of cardiovascular events, on selected steps of platelet activation.
methodsThe effects of tested extracts on adhesion of blood platelets to collagen and fibrinogen were determined according to Tuszynski and Murphy. The platelet aggregation was determined by turbidimetry method using a Chrono-log Lumi-aggregometer.
resultsWe have observed that HTL, like its precursor-Hcy stimulated the generation of O₂⁻• (measured by the superoxide dismutase-inhibitable reduction of cytochrome c) in platelets and caused an augmentation of the platelet adhesion and aggregation induced by the strong physiological agonist-thrombin. Our present results in vitro also demonstrated that the aronia extract and grape seeds extract reduced the toxicity action of Hcy and HTL on blood platelet adhesion to collagen and fibrinogen, the platelet aggregation and superoxide anion radicals production in platelets, suggesting its potential protective effects on hemostasis during hyperhomocysteinemia.
conclusionIn the comparative studies, the aronia extract was found to be more effective antiplatelet factors, than GSE or resveratrol during a model of hyperhomocysteinemia. It gives hopes for development of diet supplements, which may be important during hyperhomocysteinemia.
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