ArticleEndocrine2013
C-reactive protein concentration as a significant correlate for metabolic syndrome: a Chinese population-based study.
Article in Endocrine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Association between leisure time physical activity and metabolic syndrome: a meta-analysis of prospective cohort studies.Endocrine · 2014Pooled it
- C-reactive protein polygenic risk is associated with obesity-related traits in schizophrenia spectrum disorders.Frontiers in psychiatry · 2026Article
- Short-Term Heart Rate Variability in Metabolic Syndrome: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Associations of Thyroid Hormone Levels and Macrovascular Complications in Euthyroid Type 2 Diabetic Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Low-intensity Physical Activity is Associated with Lower Maternal Systemic Inflammation during Late Pregnancy.Journal of obesity & weight loss therapy · 2017Article
- High-sensitive C-reactive protein and risk of incident type 2 diabetes: a case-control study nested within the Singapore Chinese Health Study.BMC endocrine disorders · 2017Article
- Sex Differences in High Sensitivity C-Reactive Protein in Subjects with Risk Factors of Metabolic Syndrome.Arquivos brasileiros de cardiologia · 2016Article
- The Association of Peroxisome Proliferator-Activated Receptor δ and Additional Gene-Gene Interaction with C-Reactive Protein in Chinese Population.International journal of endocrinology · 2016Article
- Insights into the molecular mechanisms of diabetes-induced endothelial dysfunction: focus on oxidative stress and endothelial progenitor cells.Endocrine · 2015Article
- Effect of obesity on the association between common variations in the PPAR gene and C-reactive protein level in Chinese Han population.Endocrine · 2015Article
- High serum ferritin level is an independent risk factor for metabolic syndrome in a Chinese male cohort population.Diabetology & metabolic syndrome · 2015Article
- Population-based metabolic syndrome risk score and its determinants: The Isfahan Healthy Heart Program.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Association of hematological parameters with metabolic syndrome in Beijing adult population: a longitudinal study.Endocrine · 2014Article
- Comparison of high-sensitivity C-reactive protein and fetuin-A levels before and after treatment for subjects with subclinical hyperthyroidism.Endocrine · 2014Article
- Relationship of thyroid hormone levels and cardiovascular events in patients with type 2 diabetes.Endocrine · 2014Article
- Relationship between lung function and metabolic syndrome.PloS one · 2014Article
- High-Sensitivity C-Reactive Protein is Related to Central Obesity and the Number of Metabolic Syndrome Components in Jamaican Young Adults.Frontiers in cardiovascular medicine · 2014Article
- Authors reply to Dr. Kawada's comments.Endocrine · 2013Article
- Serum C-reactive protein and metabolic components.Endocrine · 2013Article
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence suggests that chronic, low-grade inflammation may be a common soil involving the pathogenesis of metabolic syndrome (MetS) and cardiovascular disease. We examined the association between C-reactive protein (CRP) concentration, an extensively studied biomarker of low-grade inflammation, and the MetS in a representative sample of Chinese adults in Taiwan. We performed a cross-sectional analysis of data from 4234 subjects [mean (±SD) age, 47.1 (±18.2) years; 46.4 % males] who participated in a population-based survey on prevalences of hypertension, hyperglycemia, and hyperlipidemia in Taiwan. CRP levels were measured by the immunoturbidimetric CRP-latex high-sensitivity assay. The MetS was defined by an unified criteria set by several major organizations. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated with logistic regression model. Overall, there were 938 subjects with MetS among 4,234 participants, resulting in a prevalence rate of 22.1 %. A significantly progressive increase in the prevalence of MetS across quartiles of CRP was observed (p for trend <0.001). Participants in the second, third, and upper quartiles of CRP had significantly higher risk of having MetS when compared with those in the lowest quartile [adjusted ORs (95 % CIs) were 2.18 (1.62-2.94), 4.39 (3.31-5.81), and 7.11 (5.39-9.38), respectively; p for trend <0.001]. Furthermore, there was a strong stepwise increase in CRP levels as the number of components of the MetS increased. The prevalence of MetS showed a graded increase according to CRP concentrations. The possible utility of CRP concentration as a marker for MetS risk awaits further evaluation in prospective studies.
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