ArticleLab on a chip2012
Microfluidic platform for on-demand generation of spatially indexed combinatorial droplets.
Article in Lab on a chip, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Emerging platforms for high-throughput enzymatic bioassays.Trends in biotechnology · 2023Review
- A microfluidic Braille valve platform for on-demand production, combinatorial screening and sorting of chemically distinct droplets.Nature protocols · 2022Review
- Facile and scalable tubing-free sample loading for droplet microfluidics.Scientific reports · 2022Article
- Automated and Dynamic Control of Chemical Content in Droplets for Scalable Screens of Small Animals.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- Combinatorial nanodroplet platform for screening antibiotic combinations.Lab on a chip · 2022Article
- Combating Antimicrobial Resistance via Single-Cell Diagnostic Technologies Powered by Droplet Microfluidics.Accounts of chemical research · 2022Article
- Deterministic assembly of chromosome ensembles in a programmable membrane trap array.Biofabrication · 2021Article
- High-throughput screening by droplet microfluidics: perspective into key challenges and future prospects.Lab on a chip · 2020Article
- Customizing droplet contents and dynamic ranges via integrated programmable picodroplet assembler.Microsystems & nanoengineering · 2019Article
- Droplet microfluidics for high-sensitivity and high-throughput detection and screening of disease biomarkers.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2018Review
- A microfluidics platform for combinatorial drug screening on cancer biopsies.Nature communications · 2018Article
- Accelerating bacterial growth detection and antimicrobial susceptibility assessment in integrated picoliter droplet platform.Biosensors & bioelectronics · 2017Article
- New and developing diagnostic technologies for urinary tract infections.Nature reviews. Urology · 2017Review
- Physiologically relevant binding affinity quantification of monoclonal antibody PF-00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation.British journal of pharmacology · 2017Article
- An acoustofluidic sputum liquefier.Lab on a chip · 2015Article
- On-demand generation and mixing of liquid-in-gas slugs with digitally-programmable composition and size.Journal of micromechanics and microengineering : structures, devices, and systems · 2015Article
- DNA-library assembly programmed by on-demand nano-liter droplets from a custom microfluidic chip.Biomicrofluidics · 2015Article
- Microfluidic continuous flow digital loop-mediated isothermal amplification (LAMP).Lab on a chip · 2015Article
- A barcode-free combinatorial screening platform for matrix metalloproteinase screening.Analytical chemistry · 2015Article
- On demand nanoliter-scale microfluidic droplet generation, injection, and mixing using a passive microfluidic device.Biomicrofluidics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We propose a highly versatile and programmable nanolitre droplet-based platform that accepts an unlimited number of sample plugs from a multi-well plate, performs digitization of these sample plugs into smaller daughter droplets and subsequent synchronization-free, robust injection of multiple reagents into the sample daughter droplets on-demand. This platform combines excellent control of valve-based microfluidics with the high-throughput capability of droplet microfluidics. We demonstrate the functioning of a proof-of-concept device which generates combinatorial mixture droplets from a linear array of sample plugs and four different reagents, using food dyes to mimic samples and reagents. Generation of a one dimensional array of the combinatorial mixture droplets on the device leads to automatic spatial indexing of these droplets, precluding the need to include a barcode in each droplet to identify its contents. We expect this platform to further expand the range of applications of droplet microfluidics to include applications requiring a high degree of multiplexing as well as high throughput analysis of multiple samples.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.