ArticleThe Journal of investigative dermatology2012
IgG autoantibody response against keratinocyte cadherins in endemic pemphigus foliaceus (fogo selvagem).
Article in The Journal of investigative dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Identification of a primary antigenic target of epitope spreading in endemic pemphigus foliaceus.Journal of autoimmunity · 2021Article
- Beyond the HLA polymorphism: A complex pattern of genetic susceptibility to pemphigus.Genetics and molecular biology · 2020Article
- Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope.Journal of autoimmunity · 2018Article
- Sparking Fire Under the Skin? Answers From the Association of Complement Genes With Pemphigus Foliaceus.Frontiers in immunology · 2018Article
- Divergent Specificity Development of IgG1 and IgG4 Autoantibodies in Endemic Pemphigus Foliaceus (Fogo Selvagem).ImmunoHorizons · 2017Article
- A 3'UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility.Biochimica et biophysica acta · 2016Article
- Mechanisms of Disease: Pemphigus and Bullous Pemphigoid.Annual review of pathology · 2016Review
- Immune response in pemphigus and beyond: progresses and emerging concepts.Seminars in immunopathology · 2016Review
- Mucosal pemphigus vulgaris anti-Dsg3 IgG is pathogenic to the oral mucosa of humanized Dsg3 mice.The Journal of investigative dermatology · 2015Article
- Update on fogo selvagem, an endemic form of pemphigus foliaceus.The Journal of dermatology · 2015Review
- Genome-wide gene expression profiling reveals unsuspected molecular alterations in pemphigus foliaceus.Immunology · 2014Article
- E-cadherin autoantibody profile in patients with pemphigus vulgaris.The British journal of dermatology · 2013Article
- Article
- Factors associated with non-pathogenic antibodies against desmoglein-3 in pemphigus foliaceus.Anais brasileiros de dermatologiaArticle
- Detection of apoptosis in pemphigus vulgaris by TUNEL technique.Anais brasileiros de dermatologiaArticle
- Fogo selvagem: endemic pemphigus foliaceus.Anais brasileiros de dermatologiaReview
- Autoantibodies against desmoglein 2 are not pathogenic in pemphigus.Anais brasileiros de dermatologiaArticle
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
It is well established that autoantibodies against desmoglein 3 and desmoglein 1 (Dsg1) are relevant in the pathogenesis of pemphigus vulgaris and pemphigus foliaceus, including its endemic form fogo selvagem (FS). Isolated reports have shown that in certain patients with these diseases, autoantibodies against other desmosomal cadherins and E-cadherin may also be present. The goal of this investigation was to determine whether FS patients and normal individuals living in endemic areas possess autoantibodies against other desmosomal cadherins and E-cadherin. By testing a large number of FS and endemic control sera by ELISA, we found a consistent and specific autoantibody response against Dsg1 and other keratinocyte cadherins in these individuals, which is quite different from healthy individuals from the United States (US controls). Overall, the highest correlations among the autoantibody responses tested were in the endemic controls, followed by FS patients, and lowest in the US controls. These findings suggest that multiple, perhaps cross-reactive, keratinocyte cadherins are recognized by FS patients and endemic controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.