ArticleThe Journal of biological chemistry2012
Short term voluntary overfeeding disrupts brain insulin control of adipose tissue lipolysis.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 67 citations in OpenAlex.
- One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men.Obesity (Silver Spring, Md.) · 2014Trial
- From Adipose Dysfunction to Multi-Organ Steatosis: Defining the Metabolic Steatotic Axis.Current issues in molecular biology · 2026Review
- Sympathetic nerve activity in obesity-associated insulin resistance.Acta pharmaceutica Sinica. B · 2025Article
- Overnutrition causes insulin resistance and metabolic disorder through increased sympathetic nervous system activity.Cell metabolism · 2025Article
- Article
- Single-cell transcriptome analysis reveals the regulatory functions of islet exocrine cells after short-time obesogenic diet.Endocrine · 2024Article
- Regulation of Insulin Clearance by Non-Esterified Fatty Acids.Biomedicines · 2022Review
- Targeting the Gut in Obesity: Signals from the Inner Surface.Metabolites · 2022Review
- Cardiovascular Diseases in Obesity: What is the Role of Magnesium?Biological trace element research · 2021Review
- Brain insulin signalling in metabolic homeostasis and disease.Nature reviews. Endocrinology · 2021Review
- Nutrient infusion in the dorsal vagal complex controls hepatic lipid and glucose metabolism in rats.iScience · 2021Article
- Article
- Impact of short-term high-fat feeding on lipid droplet content in mouse oocytes.The Journal of reproduction and development · 2021Article
- Hypothalamic Inflammation as a Potential Pathophysiologic Basis for the Heterogeneity of Clinical, Hormonal, and Metabolic Presentation in PCOS.Nutrients · 2021Review
- High Fat Rodent Models of Type 2 Diabetes: From Rodent to Human.Nutrients · 2020Review
- Anti-Lipolysis Induced by Insulin in Diverse Pathophysiologic Conditions of Adipose Tissue.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Pathogenesis of Insulin Resistance and Atherogenic Dyslipidemia in Nonalcoholic Fatty Liver Disease.Journal of clinical and translational hepatology · 2019Review
- Hypothalamic Fatty Acids and Ketone Bodies Sensing and Role of FAT/CD36 in the Regulation of Food Intake.Frontiers in physiology · 2019Review
- Regulation of Immune Cell Function by PPARs and the Connection with Metabolic and Neurodegenerative Diseases.International journal of molecular sciences · 2018Review
- Review of the role of the nervous system in glucose homoeostasis and future perspectives towards the management of diabetes.Bioelectronic medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Insulin controls fatty acid (FA) release from white adipose tissue (WAT) through direct effects on adipocytes and indirectly through hypothalamic signaling by reducing sympathetic nervous system outflow to WAT. Uncontrolled FA release from WAT promotes lipotoxicity, which is characterized by inflammation and insulin resistance that leads to and worsens type 2 diabetes. Here we tested whether early diet-induced insulin resistance impairs the ability of hypothalamic insulin to regulate WAT lipolysis and thus contributes to adipose tissue dysfunction. To this end we fed male Sprague-Dawley rats a 10% lard diet (high fat diet (HFD)) for 3 consecutive days, which is known to induce systemic insulin resistance. Rats were studied by euglycemic pancreatic clamps and concomitant infusion of either insulin or vehicle into the mediobasal hypothalamus. Short term HFD feeding led to a 37% increase in caloric intake and elevated base-line free FAs and insulin levels compared with rats fed regular chow. Overfeeding did not impair insulin signaling in WAT, but it abolished the ability of mediobasal hypothalamus insulin to suppress WAT lipolysis and hepatic glucose production as assessed by glycerol and glucose flux. HFD feeding also increased hypothalamic levels of the endocannabinoid 2-arachidonoylglycerol after only 3 days. In summary, overfeeding impairs hypothalamic insulin action, which may contribute to unrestrained lipolysis seen in human obesity and type 2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.