ReviewCurrent psychiatry reports2012
Personalized treatment of alcohol dependence.
Review in Current psychiatry reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05633186 (Sustainable Upscaling of Depression Prevention, Finding the Optimal Balance Between Investment and Benefit), which is not on this map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sustainable Upscaling of Depression Prevention, Finding the Optimal Balance Between Investment and Benefit (SPRINT)
Who cites it
46 citing papers in PubMed.
- Applying methods for personalized medicine to the treatment of alcohol use disorder.Journal of consulting and clinical psychology · 2021Trial
- An efficacy trial of adaptive interventions for alcohol use disorder.Journal of substance abuse treatment · 2021Trial
- Advancing Precision Medicine for Alcohol Use Disorder: Replication and Extension of Reward Drinking as a Predictor of Naltrexone Response.Alcoholism, clinical and experimental research · 2019Trial
- Precision Medicine in Alcohol Dependence: A Controlled Trial Testing Pharmacotherapy Response Among Reward and Relief Drinking Phenotypes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Cost-effectiveness analysis of a continuing care intervention for cocaine-dependent adults.Drug and alcohol dependence · 2016Trial
- Subgroup Identification in Personalized Treatment of Alcohol Dependence.Alcoholism, clinical and experimental research · 2015Trial
- Social network moderators of naltrexone and behavioral treatment effects on heavy drinking in the COMBINE study.Alcoholism, clinical and experimental research · 2015Trial
- Ondansetron and sertraline may interact with 5-HTTLPR and DRD4 polymorphisms to reduce drinking in non-treatment seeking alcohol-dependent women: exploratory findings.Alcohol (Fayetteville, N.Y.) · 2014Trial
- Being "SMART" About Adolescent Conduct Problems Prevention: Executing a SMART Pilot Study in a Juvenile Diversion Agency.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Trial
- Forecasting alcohol lapse risk up to two weeks in advance using time-lagged machine learning models.PloS one · 2026Article
- Do improvements in motivational language predict alcohol use in motivational interviewing? Ambivalence matters.Journal of consulting and clinical psychology · 2024Article
- A MARGINAL STRUCTURAL MODEL FOR PARTIAL COMPLIANCE IN SMARTS.The annals of applied statistics · 2024Article
- Beyond mediators: A critical review and methodological path forward for studying mechanisms in alcohol use treatment research.Alcohol, clinical & experimental research · 2024Review
- Improving Social Recovery Capital Research To Enhance Clinical Utility: A Proposed Agenda.Addiction research & theory · 2024Article
- Nonparametric Bayesian Q-learning for optimization of dynamic treatment regimes in the presence of partial compliance.Statistical methods in medical research · 2023Article
- Constructs derived from the addiction cycle predict alcohol use disorder treatment outcomes and recovery 3 years following treatment.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023Article
- Selective ablation of VIP interneurons in the rodent prefrontal cortex results in increased impulsivity.PloS one · 2023Article
- Mechanisms of Behavior Change in Substance Use Disorder With and Without Formal Treatment.Annual review of clinical psychology · 2022Review
- Bayesian set of best dynamic treatment regimes: Construction and sample size calculation for SMARTs with binary outcomes.Statistics in medicine · 2022Article
- Individual differences in the effects of the ACTION-PAC intervention: an application of personalized medicine in the prevention and treatment of obesity.Journal of behavioral medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Pharmacogenetic and adaptive treatment approaches can be used to personalize care for alcohol-dependent patients. Preliminary evidence shows that variation in the gene encoding the μ-opioid receptor moderates the response to naltrexone when used to treat alcohol dependence. Studies have also shown moderating effects of variation in the gene encoding the serotonin transporter on response to serotonergic treatment of alcohol dependence. Adaptive algorithms that modify alcohol treatment based on patients' progress have also shown promise. Initial response to outpatient treatment appears to be a particularly important in the selection of optimal continuing care interventions. In addition, stepped-care algorithms can reduce the cost and burden of treatment while maintaining good outcomes. Finally, matching treatment to specific problems present at intake or that emerge during treatment can also improve outcomes. Although all of these effects require replication and further refinement, the future of personalized care for alcohol dependence appears bright.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.