ArticleBiology letters2013
Epistasis between mutations is host-dependent for an RNA virus.
Article in Biology letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 70 citations in OpenAlex.
- Compensatory evolution to DNA replication stress is robust to nutrient availability.Molecular systems biology · 2025Article
- The importance of epistasis in the evolution of viral pathogens.Virus evolution · 2025Review
- Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda's fitness landscape and enables speciation.Nature communications · 2024Article
- Genetic basis ofeLife · 2024Article
- Increasing temperature alters the within-host competition of viral strains and influences virus genetic variability.Virus evolution · 2021Article
- Proteostasis Environment Shapes Higher-Order Epistasis Operating on Antibiotic Resistance.Genetics · 2019Article
- Feature Learning of Virus Genome Evolution With the Nucleotide Skip-Gram Neural Network.Evolutionary bioinformatics online · 2019Article
- Analysis of Fitness Trade-Offs in the Host Range Expansion of an RNA Virus, Tobacco Mild Green Mosaic Virus.Journal of virology · 2018Article
- Article
- Mechanisms and Concepts in RNA Virus Population Dynamics and Evolution.Annual review of virology · 2018Review
- Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution.Microbiology and molecular biology reviews : MMBR · 2018Review
- Viral Fitness Correlates with the Magnitude and Direction of the Perturbation Induced in the Host's Transcriptome: The Tobacco Etch Potyvirus-Tobacco Case Study.Molecular biology and evolution · 2018Article
- Multi-environment fitness landscapes of a tRNA gene.Nature ecology & evolution · 2018Article
- Article
- Evolutionary ecology of virus emergence.Annals of the New York Academy of Sciences · 2017Review
- Adaptation of avian influenza virus to a swine host.Virus evolution · 2017Article
- Effect of Host Species on Topography of the Fitness Landscape for a Plant RNA Virus.Journal of virology · 2016Article
- Epistatic Interactions in the Arabinose Cis-Regulatory Element.Molecular biology and evolution · 2016Article
- The Role of Recombination in Evolutionary Rescue.Genetics · 2016Article
- Multiple Resistance at No Cost: Rifampicin and Streptomycin a Dangerous Liaison in the Spread of Antibiotic Resistance.Molecular biology and evolution · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How, and to what extent, does the environment influence the way mutations interact? Do environmental changes affect both the sign and the magnitude of epistasis? Are there any correlations between environments in the variability, sign or magnitude of epistasis? Very few studies have tackled these questions. Here, we addressed them in the context of viral emergence. Most emerging viruses are RNA viruses with small genomes, overlapping reading frames and multifunctional proteins for which epistasis is abundant. Understanding the effect of host species in the sign and magnitude of epistasis will provide insights into the evolutionary ecology of infectious diseases and the predictability of viral emergence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.