ArticleJournal of psychiatric research2012
Post-traumatic stress disorder and medication adherence: results from the Mind Your Heart study.
Article in Journal of psychiatric research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Early interventions to prevent posttraumatic stress disorder symptoms in survivors of life-threatening medical events: A systematic review.Journal of anxiety disorders · 2019Pooled it
- PTSD in prison settings: A systematic review and meta-analysis of comorbid mental disorders and problematic behaviours.PloS one · 2019Pooled it
- Posttraumatic stress disorder and nonadherence to medications prescribed for chronic medical conditions: A meta-analysis.Journal of psychiatric research · 2018Pooled it
- Prevalence of Posttraumatic Stress Disorder in Prisoners.Epidemiologic reviews · 2018Pooled it
- A systematic review of the inclusion of mechanisms of action in NIH-funded intervention trials to improve medication adherence.Behaviour research and therapy · 2018Pooled it
- Posttraumatic stress disorder and risk for coronary heart disease: a meta-analytic review.American heart journal · 2013Pooled it
- Posttraumatic stress disorder in organ transplant recipients: a systematic review.General hospital psychiatryPooled it
- Trial
- Amygdala-related electroencephalogram neurofeedback as add-on therapy for treatment-resistant childhood sexual abuse posttraumatic stress disorder: feasibility study.Psychiatry and clinical neurosciences · 2024Trial
- The PTSD-Bone Axis: Evidence, Mechanisms, and Management.Current osteoporosis reports · 2026Review
- High prevalence of posttraumatic stress disorder in survivors of aneurysmal subarachnoid hemorrhage: a 6-month follow-up screening study.Acta neurologica Belgica · 2026Review
- Review
- Oral health knowledge and practices of women with children who are internally displaced, refugees, and migrants in Nigeria: a cross-sectional study.BMC oral health · 2025Article
- Phase 1 clinical trial on Orgasmic Meditation (OM): Assessing safety and feasibility as a meditation practice for individuals with PTSD.Contemporary clinical trials communications · 2025Article
- Article
- Clinical Education: Addressing Prior Trauma and Its Impacts in Medical Settings.Journal of clinical psychology in medical settings · 2024Review
- Psychophysiological effects of equine-facilitated psychotherapy on Veterans with PTSD and their horse partners.Journal of military, veteran and family health · 2024Article
- Post-traumatic stress disorder symptoms are frequent among inflammatory bowel disease patients of South Asian descent-A case-control study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Article
- Health insurance, perceived threat, and posttraumatic stress after suspected acute coronary syndrome.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Observational
- Prevalence, correlates, and mental and physical health burden of cardiovascular disease in older U.S. military veterans.PLOS mental health · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundPatients with post-traumatic stress disorder (PTSD) are at increased risk for adverse outcomes from comorbid medical conditions. Medication non-adherence is a potential mechanism explaining this increased risk.
methodsWe examined the association between PTSD and medication adherence in a cross-sectional study of 724 patients recruited from two Department of Veterans Affairs Medical Centers between 2008 and 2010. PTSD was assessed using the Clinician Administered PTSD Scale. Medication adherence was assessed using a standardized questionnaire. Ordinal logistic regression models were used to calculate the odds ratios (ORs) for medication non-adherence in patients with versus without PTSD, adjusting for potential confounders.
resultsA total of 252 patients (35%) had PTSD. Twelve percent of patients with PTSD reported not taking their medications as prescribed compared to 9% of patients without PTSD (unadjusted OR 1.85, 95% CI 1.37-2.50, P<0.001). Forty-one percent of patients with PTSD compared to 29% of patients without PTSD reported forgetting medications (unadjusted OR 1.90, 95% CI 1.44-2.52, P<0.001). Patients with PTSD were also more likely to report skipping medications (24% versus 13%; unadjusted OR 2.01, 95% CI 1.44-2.82, P<0.001). The association between PTSD and non-adherence remained significant after adjusting for demographics, depression, alcohol use, social support, and medical comorbidities (adjusted OR 1.47, 95% CI 1.03-2.10, P=0.04 for not taking medications as prescribed and 1.95, 95% CI 1.31-2.91, P=0.001 for skipping medications).
conclusionsPTSD was associated with medication non-adherence independent of psychiatric and medical comorbidities. Medication non-adherence may contribute to the increased morbidity and mortality observed in patients with PTSD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.