Evidence map›Paper›PMID 22809209›Full record

ReviewExpert review of proteomics2012

Insights into the virulence of oral biofilms: discoveries from proteomics.

Masae Kuboniwa, Gena D Tribble, Erik L Hendrickson, Atsuo Amano, Richard J Lamont, Murray Hackett

Abstract readReview
In one paragraph

Review in Expert review of proteomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Antibacterial activity ofFuture microbiology · 2024
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Oral Microbiota Profile of Individuals Who Abuse Methamphetamine.Frontiers in cellular and infection microbiology · 2021
    Article
  10. Profuse diversity and acidogenicity of theJournal of oral microbiology · 2021
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. A new era in palaeomicrobiology: prospects for ancient dental calculus as a long-term record of the human oral microbiome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Masae KuboniwaDepartment of Preventive Dentistry, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan. kuboniwa@dent.osaka-u.ac.jp
Gena D Tribble
Erik L Hendrickson
Atsuo Amano
Richard J Lamont
Murray Hackett

Funding

MOLECULAR ASPECTS OF ORAL PLAQUE FORMATIONR01DE012505 · NIDCR · UNIVERSITY OF WASHINGTON · PI Richard J Lamont, JAN S POTEMPA · 1998 to 2026
$9.5M
P GINGIVALIS INTERACTIONS WITH GINGIVAL EPITHELIAL CELLSR01DE011111 · NIDCR · UNIVERSITY OF WASHINGTON · PI HARIBABU BODDULURI, Richard J Lamont · 1995 to 2026
$5.4M
Proteomics of Porphyromonas gingivalis interactions with Fusobacterium nucleatumR01DE014372 · NIDCR · UNIVERSITY OF WASHINGTON · PI HACKETT, MURRAY · 2003 to 2014
$3.7M
P.gingivalis Interactions with Gingival Epithelial CellsR37DE011111 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2009 to 2018
$3.6M
Proteomics of P. gingivalis interactions with F. nucleatum and S. gordoniiR56DE014372 · NIDCR · UNIVERSITY OF WASHINGTON · PI HACKETT, MURRAY · 2009 to 2015
$1.2M
Pathogenic mechanisms of F. alocisR21DE022867 · NIDCR · UNIVERSITY OF LOUISVILLE · PI LAMONT, RICHARD J · 2012 to 2013
$404k
NIDCR NIH HHS DE014372NIDCR NIH HHS DE11111NIDCR NIH HHS R01 DE011111NIDCR NIH HHS R01 DE012505NIDCR NIH HHS R01 DE014372NIDCR NIH HHS R21 DE022867NIDCR NIH HHS R37 DE011111NIDCR NIH HHS R56 DE014372
6 · The paper itself

Abstract

This review covers developments in the study of polymicrobial communities, biofilms and selected areas of host response relevant to dental plaque and related areas of oral biology. The emphasis is on recent studies in which proteomic methods, particularly those using mass spectrometry as a readout, have played a major role in the investigation. The last 5-10 years have seen a transition of such methods from the periphery of oral biology to the mainstream, as in other areas of biomedical science. For reasons of focus and space, the authors do not discuss biomarker studies relevant to improved diagnostics for oral health, as this literature is rather substantial in its own right and deserves a separate treatment. Here, global gene regulation studies of plaque-component organisms, biofilm formation, multispecies interactions and host-microbe interactions are discussed. Several aspects of proteomics methodology that are relevant to the studies of multispecies systems are commented upon.

Indexed as

Host-Pathogen InteractionsBiofilmsDental PlaqueFusobacterium nucleatumGram-Negative Anaerobic BacteriaHumansMicrobial InteractionsPeriodontal DiseasesPorphyromonas gingivalisPrevotella intermediaProteomicsTreponema denticolaVirulence

Identifiers

PMID22809209
PMCPMC3555135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.