ArticleExpert review of proteomics2012
ETD fragmentation features improve algorithm.
Article in Expert review of proteomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Electron transfer dissociation (ETD) is an alternative technique used in mass spectrometry-based proteomics experiments. Because it is newer, most of the protein identification algorithms for ETD are still a simple derivation of well-established collision-activated dissociation algorithms without the consideration of many unique ETD spectral features. Sridhara and coworkers recently reported removing the charge-reduced precursors and corresponding neutral loss peaks to improve ETD peptide identification with the Open Mass Spectrometry Search Algorithm (OMSSA). These peaks were also used to deduce the charge of the precursors for low resolution data. The scheme is a concrete example of implementing known ETD fragmentation features to improve a protein identification algorithm.
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