ArticleFEMS immunology and medical microbiology2012
Role of Vpma phase variation in Mycoplasma agalactiae pathogenesis.
Article in FEMS immunology and medical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Exploring the pangenome of Mycoplasma hyorhinis in search of potential virulence markers.Scientific reports · 2025Article
- Immune Responses Induced by Recombinant Membrane Proteins ofVaccines · 2025Article
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- Single-cell analysis of multiple invertible promoters reveals differential inversion rates as a strong determinant of bacterial population heterogeneity.Science advances · 2023Article
- Serum Resistance ofPathogens (Basel, Switzerland) · 2022Article
- Sheep Infection Trials with 'Phase-Locked' Vpma Expression Variants ofMicroorganisms · 2022Article
- Predominant Single Stable VpmaV Expression in Strain GM139 and Major Differences withAnimals : an open access journal from MDPI · 2022Article
- Nicotinamide Adenine Dinucleotide-Dependent Flavin Oxidoreductase ofFrontiers in microbiology · 2021Article
- Antimicrobial Resistance inMicrobiology spectrum · 2018Review
- Vpma phase variation is important for survival and persistence of Mycoplasma agalactiae in the immunocompetent host.PLoS pathogens · 2017Article
- Article
- Genetic loci of Mycoplasma agalactiae involved in systemic spreading during experimental intramammary infection of sheep.Veterinary research · 2016Article
- Simultaneous Identification of Potential Pathogenicity Factors of Mycoplasma agalactiae in the Natural Ovine Host by Negative Selection.Infection and immunity · 2015Article
- Article
- In vitro and in vivo cell invasion and systemic spreading of Mycoplasma agalactiae in the sheep infection model.International journal of medical microbiology : IJMM · 2014Article
- Article
- Experimental infections with Mycoplasma agalactiae identify key factors involved in host-colonization.PloS one · 2014Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Compared with other bacterial pathogens, the molecular mechanisms of mycoplasma pathogenicity are largely unknown. Several studies in the past have shown that pathogenic mycoplasmas are equipped with sophisticated genetic systems that allow them to undergo high-frequency surface antigenic variations. Although never clearly proven, these variable mycoplasma surface components are often implicated in host immune evasion and adaptation. Vpma surface lipoproteins of the ruminant pathogen Mycoplasma agalactiae are encoded on a genomic pathogenicity island-like locus and are considered as one of the well-characterized model systems of mycoplasma surface antigenic variation. The present study assesses the role of these phase-variable Vpmas in the molecular pathogenesis of M. agalactiae by testing the wild-type strain PG2 in comparison with the xer1-disrupted Vpma 'phase-locked' mutants in sheep infection models. The data clearly illustrate that although Xer1 recombinase is not a virulence factor of M. agalactiae and Vpma phase variation is not necessary for establishing an infection, it might critically influence the survival and persistence of the pathogen under natural field conditions, mainly due to a better capacity for dissemination and evoking systemic responses. This is the first study where mycoplasma 'phase-locked' mutants are tested in vivo to elucidate the role of phase variation during infection.
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