ArticleCommunicative & integrative biology2012
Putative cell wall integrity sensor proteins in Aspergillus nidulans.
Article in Communicative & integrative biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Comparative Transcriptomic Analyses Propose the Molecular Regulatory Mechanisms Underlying 1,8-Cineole fromMolecules (Basel, Switzerland) · 2023Review
- Cell Wall Integrity and Its Industrial Applications in Filamentous Fungi.Journal of fungi (Basel, Switzerland) · 2022Review
- Dynamic Transcriptomic and Phosphoproteomic Analysis During Cell Wall Stress inMolecular & cellular proteomics : MCP · 2020Article
- A WDR Gene Is a Conserved Member of a Chitin Synthase Gene Cluster and Influences the Cell Wall in Aspergillus nidulans.International journal of molecular sciences · 2016Article
- Neurospora crassa 1,3-α-glucan synthase, AGS-1, is required for cell wall biosynthesis during macroconidia development.Microbiology (Reading, England) · 2014Article
- Comparative genomic and transcriptomic analysis of wangiella dermatitidis, a major cause of phaeohyphomycosis and a model black yeast human pathogen.G3 (Bethesda, Md.) · 2014Article
- The capacity ofFungal biology and biotechnology · 2014Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cell wall integrity (CWI) signal transduction pathway, which has been well-studied in the yeast Saccharomyces cerevisiae, plays an important role in the regulation of cell wall biogenesis. Recently, we characterized the CWI stress sensor orthologs WscA and WscB in the filamentous fungus Aspergillus nidulans. Disruption of the wscA and wscB genes causes a change in the transcriptional levels of agsA and agsB, which encode α-1,3-glucan synthase, resulting in an increase in alkaline soluble cell wall glucan. However, the contribution of these putative sensors to downstream CWI pathway signaling remains unclear because MpkA-RlmA signaling remains active in wscA-wscB double disruptants exposed to cell wall stress associated with exposure to micafungin, a potent inhibitor of β-1,3-glucan synthase. In this addendum, we report the results of further studies involving hypo-osmotic shock as a stressor that suggest WscA and WscB are not essential for MpkA-RlmA signaling. Finally, we describe for the first time other Aspergillus CWI stress sensor candidate Mid2-like protein.
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Registered trials
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