ArticlePloS one2012
Influence of socioeconomic status on survival of hepatocellular carcinoma in the Ontario population; a population-based study, 1990-2009.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05128123 (Influence of Social Determinants of Health on the Management of Hepatocellular Carcinoma in the French National Cohort Study CHIEF), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Social Determinants of Health on the Management of Hepatocellular Carcinoma in the French National Cohort Study CHIEF
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Understanding the social determinants of health among Indigenous Canadians: priorities for health promotion policies and actions.Global health action · 2015Pooled it
- Factors Explaining Socio-Economic Inequalities in Cancer Survival: A Systematic Review.Cancer control : journal of the Moffitt Cancer CenterPooled it
- Machine Learning Predicts Hepatocellular Carcinoma Risk from Routine Clinical Data: A Large Population-Based Multicentric Study.Cancer discovery · 2026Article
- Probabilistic bias analysis for exposure misclassification of household income by neighbourhood in a cohort of individuals with colorectal cancer.International journal of epidemiology · 2024Article
- Factors Associated with Primary Liver Cancer Survival in a Southern Italian Setting in a Changing Epidemiological Scenario.Cancers · 2024Article
- Stigmatization of drinking patients with liver cancer: The role of socioeconomic status.Heliyon · 2024Article
- Social Inequities in the Survival of Liver Cancer: A Nationwide Cohort Study in Korea, 2007-2017.Journal of Korean medical science · 2024Article
- The Impact of Socioeconomic Status on Mortality in Patients with Hepatocellular Carcinoma: A Korean National Cohort Study.Gut and liver · 2022Article
- Population-Based Cancer Survival in Canada and the United States by Socioeconomic Status: Findings from the CONCORD-2 Study.Journal of registry management · 2022Article
- Socioeconomic Environment and Survival in Patients with Digestive Cancers: A French Population-Based Study.Cancers · 2021Article
- Does low income effects 5-year mortality of hepatocellular carcinoma patients?International journal for equity in health · 2021Article
- Developing Priorities for Palliative Care Research in Advanced Liver Disease: A Multidisciplinary Approach.Hepatology communications · 2021Review
- An Analysis of Individual and Contextual-Level Disparities in Screening, Treatment, and Outcomes for Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2021Review
- Treatment choices and outcomes of non-metastatic hepatocellular carcinoma patients in relationship to neighborhood socioeconomic status: a population-based study.International journal of clinical oncology · 2020Article
- The impact of socioeconomic status on outcomes in hepatocellular carcinoma: Inferences from primary insurance.Cancer medicine · 2019Article
- Care of acute conditions and chronic diseases in Canada and the United States: Rapid systematic review and meta-analysis.Journal of public health research · 2019Article
- The Impact of Race on Survival After Hepatocellular Carcinoma in a Diverse American Population.Digestive diseases and sciences · 2018Article
- Cost-effectiveness analysis of potentially curative and combination treatments for hepatocellular carcinoma with person-level data in a Canadian setting.Cancer medicine · 2017Article
- Article
- How admissions to various medical specialty divisions determines the outcome of patients with hepatocellular carcinoma: results from a retrospective study in a large hospital of northwest China.Therapeutics and clinical risk management · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResearch has shown that people from higher socioeconomic status (SES) have better hepatocellular carcinoma (HCC) survival outcomes, although no such research has been carried out in Canada. We aimed to assess if an association between SES and HCC survival existed in the Canadian context. METHODOLOGY/PRINCIPAL
findingsWe conducted a population-based cohort study linking HCC cases identified in the Ontario Cancer Registry between 1990 and 2009 to administrative and hospital data. Logistic regression and chi-squared tests were used to evaluate associations between SES (income quintile) and covariates. The Kaplan-Meier method was used to estimate survival. Sequential analysis of the proportional-hazards models were used to determine the association between SES and HCC survival controlling for potential prognostic covariates. During the period 1990-2009, 5,481 cases of HCC were identified. A significant association was found between SES and curative treatment (p = 0.0003), but no association was found between SES and non-curative treatment (p = 0.064), palliative treatment (p = 0.680), or ultrasound screening (p = 0.615). The median survival for the lowest SES was 8.5 months, compared to 8.8 months for the highest SES group. The age- and sex-adjusted proportional-hazards model showed statistically significant difference in HCC survival among the SES groups, with hazard ratio 0.905 (95% confidence intervals 0.821, 0.998) when comparing highest to lowest SES group. Further adjustments indicated that potentially curative treatment was the likely explanation for the association between SES and HCC survival. CONCLUSIONS/SIGNIFICANCE: Our findings suggest that a 10% HCC survival advantage exists for the higher SES groups. This association between SES and HCC survival is most likely a reflection of lack of access to care for low SES groups, revealing inequities in the Canadian healthcare system.
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