ArticlePloS one2012
Immune response and anti-microbial peptides expression in Malpighian tubules of Drosophila melanogaster is under developmental regulation.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Review
- NSD Overexpression in the Fat Body Increases Antimicrobial Peptide Production by the Immune Deficiency Pathway inInternational journal of molecular sciences · 2023Article
- Malpighian tubules ofFrontiers in insect science · 2023Review
- Recent trends in insect gut immunity.Frontiers in immunology · 2023Review
- Aedes aegypti Malpighian tubules are immunologically activated following systemic Toll activation.Parasites & vectors · 2022Article
- Article
- Critical Roles of Spätzle5 in Antimicrobial Peptide Production AgainstFrontiers in immunology · 2021Article
- Antimicrobial Peptides: A New Hope in Biomedical and Pharmaceutical Fields.Frontiers in cellular and infection microbiology · 2021Review
- TmRelish is required for regulating the antimicrobial responses to Escherichia coli and Staphylococcus aureus in Tenebrio molitor.Scientific reports · 2020Article
- Activation of mosquito immunity blocks the development of transmission-stage filarial nematodes.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- IIV-6 Inhibits NF-κB Responses inViruses · 2019Article
- Molecular basis for efficacy of Guduchi and Madhuyashti feeding on different environmental stressors in Drosophila.Cell stress & chaperones · 2019Article
- Distinct Functions ofFrontiers in immunology · 2019Article
- Overexpression of antimicrobial peptides contributes to aging through cytotoxic effects in Drosophila tissues.Archives of insect biochemistry and physiology · 2018Article
- Yorkie Regulates Neurodegeneration Through Canonical Pathway and Innate Immune Response.Molecular neurobiology · 2018Article
- Modeling Renal Disease "On the Fly".BioMed research international · 2018Review
- TmCactin plays an important role in Gram-negative and -positive bacterial infection by regulating expression of 7 AMP genes in Tenebrio molitor.Scientific reports · 2017Article
- The orange spotted cockroach (Proceedings of the West Virginia Academy of Science · 2017Article
- Wolbachia-Based Dengue Virus Inhibition Is Not Tissue-Specific in Aedes aegypti.PLoS neglected tropical diseases · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malpighian tubules (MT) of Drosophila melanogaster are osmoregulatory organs that maintain the ionic balance and remove toxic substances from the body. Additionally they act as autonomous immune sensing organs, which secrete antimicrobial peptides in response to invading microbial pathogens. We show that the antimicrobial peptides (AMP) diptericin, cecropinA, drosocin and attacinA are constitutively expressed and are regulated in developmental stage specific manner. Their developmental expression begins from 3(rd) instar larval stage and an immune challenge increases the expression several folds. Spatial variations in the level of expression along the MT tissue are observed. The mortality of 3(rd) instar larvae fed on bacterial food is much less than that of the earlier larval stages, coinciding with the onset of innate immunity response in MT. Ectopic expression of AMP imparts better resistance to infection while, loss of function of one of the AMP through directed RNAi reduces host survival after immune challenge. The AMP secreted from the MT exhibit bactericidal activity. Expression of the NF-κB transcription factor, Relish, also coincides with activation of immune responsive genes in MT, demonstrating that immune regulation in MT is under developmental control and is governed by the Imd pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.