ArticlePloS one2012
Sleep phenotyping in a mouse model of extreme trait anxiety.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Distinct EEG Features and Sleep/Wake Behaviour Predict Anxiety Phenotypes in Mice.Journal of sleep research · 2026Article
- Sleep is a therapeutic window for photostimulation of drainage of aging brain.Frontiers of optoelectronics · 2025Article
- Spontaneous spike-and-wave discharges during sleep in mice: circadian distribution and impact on sleep quality.Frontiers in neurology · 2025Article
- The relationship between trait anxiety and sleep quality in college students: an exploratory analysis of physical activity as a moderator.Frontiers in psychiatry · 2025Article
- Technology of the photobiostimulation of the brain's drainage system during sleep for improvement of learning and memory in male mice.Biomedical optics express · 2024Article
- Hydrogen-rich water improves sleep consolidation and enhances forebrain neuronal activation in mice.Sleep advances : a journal of the Sleep Research Society · 2024Article
- An α-hemoglobin-derived peptide (m)VD-hemopressin (α) promotes NREM sleep via the CBFrontiers in pharmacology · 2023Article
- Altered sleep behavior in a genetic mouse model of impaired fear extinction.Scientific reports · 2021Article
- Sleep-wake characteristics in a mouse model of severe traumatic brain injury: Relation to posttraumatic epilepsy.Epilepsia open · 2021Article
- Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice.Genes, brain, and behavior · 2020Article
- Neuropeptide S Counteracts Paradoxical Sleep Deprivation-Induced Anxiety-Like Behavior and Sleep Disturbances.Frontiers in cellular neuroscience · 2018Article
- Caffeine and Modafinil Ameliorate the Neuroinflammation and Anxious Behavior in Rats during Sleep Deprivation by Inhibiting the Microglia Activation.Frontiers in cellular neuroscience · 2018Article
- A simplified microwave-based motion detector for home cage activity monitoring in mice.Journal of biological engineering · 2017Article
- Fluoxetine normalizes disrupted light-induced entrainment, fragmented ultradian rhythms and altered hippocampal clock gene expression in an animal model of high trait anxiety- and depression-related behavior.Annals of medicine · 2016Article
- d-amino acid oxidase knockout (Dao(-/-) ) mice show enhanced short-term memory performance and heightened anxiety, but no sleep or circadian rhythm disruption.The European journal of neuroscience · 2015Article
- Adult neurogenesis and mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Review
- Circadian abnormalities in a mouse model of high trait anxiety and depression.Annals of medicine · 2014Article
- Analyzing gene expression data in mice with the Neuro Behavior Ontology.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- Animal models of sleep disorders.Comparative medicine · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is accumulating evidence that anxiety impairs sleep. However, due to high sleep variability in anxiety disorders, it has been difficult to state particular changes in sleep parameters caused by anxiety. Sleep profiling in an animal model with extremely high vs. low levels of trait anxiety might serve to further define sleep patterns associated with this psychopathology. METHODOLOGY/PRINCIPAL
findingsSleep-wake behavior in mouse lines with high (HAB), low (LAB) and normal (NAB) anxiety-related behaviors was monitored for 24 h during baseline and recovery after 6 h sleep deprivation (SD). The amounts of each vigilance state, sleep architecture, and EEG spectral variations were compared between the mouse lines. In comparison to NAB mice, HAB mice slept more and exhibited consistently increased delta power during non-rapid eye movement (NREM) sleep. Their sleep patterns were characterized by heavy fragmentation, reduced maintenance of wakefulness, and frequent intrusions of rapid eye movement (REM) sleep. In contrast, LAB mice showed a robust sleep-wake rhythm with remarkably prolonged sleep latency and a long, persistent period of wakefulness. In addition, the accumulation of delta power after SD was impaired in the LAB line, as compared to HAB mice. CONCLUSIONS/SIGNIFICANCE: Sleep-wake patterns were significantly different between HAB and LAB mice, indicating that the genetic predisposition to extremes in trait anxiety leaves a biological scar on sleep quality. The enhanced sleep demand observed in HAB mice, with a strong drive toward REM sleep, may resemble a unique phenotype reflecting not only elevated anxiety but also a depression-like attribute.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.