ArticlePloS one2012
Ecdysone induced gene expression is associated with acetylation of histone H3 lysine 23 in Drosophila melanogaster.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Transcriptional induction by ecdysone in Drosophila salivary glands involves an increase in chromatin accessibility and acetylation.Nucleic acids research · 2025Article
- N-alpha-acetyltransferase 40 modulates ecdysteroid action through chromatin accessibility changes near the promoters of 20-hydroxyecdysone response genes in Tribolium Castaneum TcA cells.Insect biochemistry and molecular biology · 2025Article
- Azadirachtin disrupts ecdysone signaling and alters sand fly immunity.Parasites & vectors · 2024Article
- Coregulators Reside withinInternational journal of molecular sciences · 2023Article
- Transcriptional Activation of Ecdysone-Responsive Genes Requires H3K27 Acetylation at Enhancers.International journal of molecular sciences · 2022Article
- Mitochondrial aconitase 1 regulates age-related memory impairment via autophagy/mitophagy-mediated neural plasticity in middle-aged flies.Aging cell · 2021Article
- Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex.Immunity · 2021Article
- Epigenetic regulation of post-embryonic development.Current opinion in insect science · 2021Review
- Histone deacetylase 3 is required for development and metamorphosis in the red flour beetle, Tribolium castaneum.BMC genomics · 2020Article
- Histone Deacetylase 11 Knockdown Blocks Larval Development and Metamorphosis in the Red Flour Beetle,Frontiers in genetics · 2020Article
- Histone deacetylase 1 suppresses Krüppel homolog 1 gene expression and influences juvenile hormone action inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Histone acetyltransferase CBP-related H3K23 acetylation contributes to courtship learning in Drosophila.BMC developmental biology · 2018Article
- CREB-binding protein plays key roles in juvenile hormone action in the red flour beetle, Tribolium Castaneum.Scientific reports · 2018Article
- Multiple functions of CREB-binding protein during postembryonic development: identification of target genes.BMC genomics · 2017Article
- Histone H3 lysine 23 acetylation is associated with oncogene TRIM24 expression and a poor prognosis in breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Diverse Hormone Response Networks in 41 Independent Drosophila Cell Lines.G3 (Bethesda, Md.) · 2016Article
- Regulation of maintenance DNA methylation via histone ubiquitylation.Journal of biochemistry · 2016Review
- CBP binding outside of promoters and enhancers in Drosophila melanogaster.Epigenetics & chromatin · 2015Article
- Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factor spire.Genes & development · 2014Article
- A set of structural features defines the cis-regulatory modules of antenna-expressed genes in Drosophila melanogaster.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Posttranslational modification of histones regulates transcription but the exact role that acetylation of specific lysine residues plays in biological processes in vivo is still not clearly understood. To assess the contribution of different histone modifications to transcriptional activation in vivo, we determined the acetylation patterns on the ecdysone induced Eip74EF and Eip75B genes in Drosophila melanogaster larvae by chromatin immunoprecipitation. We found that acetylation of histone H3 lysine 23 is localized to promoters and correlates with endogenous ecdysone induced gene activation. In contrast, acetylation of lysines 8, 12 and 16 of histone H4 and lysine 9 of histone H3 showed minor differences in their distribution on the regulatory and transcribed regions tested, and had limited or no correlation with ecdysone induced transcriptional activity. We found that dCBP, which is encoded by the nejire gene, acetylates H3 lysine 23 in vivo, and silencing of nejire leads to reduced expression of the Eip74EF and Eip75B genes. Our results suggest that acetylation of specific lysine residues of histones contribute specifically to the dynamic regulation of transcription. Furthermore, along with previous studies identify CBP dependent H3 lysine 23 acetylation as an evolutionarily conserved chromatin modification involved in steroid induced gene activation.
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