ArticlePloS one2012
Disentangling depression and distress networks in the tinnitus brain.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Correlation Between Chronic Tinnitus Distress and Symptoms of Depression: A Systematic Review.Frontiers in neurology · 2022Pooled it
- Transcranial direct current stimulation in tinnitus patients: a systemic review and meta-analysis.TheScientificWorldJournal · 2012Pooled it
- A clinical trial of a patient-customized virtual reality intervention for tinnitus.Scientific reports · 2022Trial
- BOLD fMRI effects of transcutaneous vagus nerve stimulation in patients with chronic tinnitus.PloS one · 2018Trial
- Vagus Nerve Stimulation Paired with Tones for the Treatment of Tinnitus: A Prospective Randomized Double-blind Controlled Pilot Study in Humans.Scientific reports · 2017Trial
- The added value of auditory cortex transcranial random noise stimulation (tRNS) after bifrontal transcranial direct current stimulation (tDCS) for tinnitus.Journal of neural transmission (Vienna, Austria : 1996) · 2017Trial
- EEG microstates and dynamic functional connectivity reveal stage-specific brain networks in subjective tinnitus.iScience · 2026Article
- Tinnitus and tinnitus disorder: Genetic, neurobiological, and clinical differentiation.iScience · 2026Review
- Tinnitus.Nature reviews. Disease primers · 2026Review
- Distinct neural circuits processing pleasant and unpleasant sounds: an fMRI-based approach.BMC neuroscience · 2025Article
- Severity, Age, Sex, Sleep, Anxiety, and Their Correlation Analysis of 1739 Tinnitus Patients.Laryngoscope investigative otolaryngology · 2025Article
- A retrospective two-center cohort study of the bidirectional relationship between depression and tinnitus-related distress.Communications medicine · 2024Article
- Pulsatile Tinnitus: Differential Diagnosis and Approach to Management.Current pain and headache reports · 2024Review
- Tinnitus: Clinical Insights in Its Pathophysiology-A Perspective.Journal of the Association for Research in Otolaryngology : JARO · 2024Review
- A parahippocampal-sensory Bayesian vicious circle generates pain or tinnitus: a source-localized EEG study.Brain communications · 2023Article
- Low Sleep Satisfaction Is Related to High Disease Burden in Tinnitus.International journal of environmental research and public health · 2022Article
- Tinnitus and the Triple Network Model: A Perspective.Clinical and experimental otorhinolaryngology · 2022Review
- Recovering Hidden Responder Groups in Individuals Receiving Neurofeedback for Tinnitus.Frontiers in neuroscience · 2022Article
- The balance between Bayesian inference and default mode determines the generation of tinnitus from decreased auditory input: A volume entropy-based study.Human brain mapping · 2021Article
- Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus.Human brain mapping · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tinnitus is the continuous perception of an internal auditory stimulus. This permanent sound often affects a person's emotional state inducing distress and depressive feelings changes in 6-25% of the affected population. Distress and depression are two distinct emotional states. Whereas distress describes a transient aversive state, interfering with a person's ability to adequately adapt to stressors, depressive feelings should rather be considered as a more constant emotional state. Based on previous observations in chronic pain, posttraumatic stress disorder and depression, we assume that both states are related to separate neural circuits. We used the Dutch version of the Tinnitus Questionnaire to assess the global index of distress together with the Beck Depression Inventory to evaluate the depressive symptoms accompanying tinnitus. Furthermore sLORETA analysis was performed to correlate current density distribution with distress and depression scores, revealing a lateralization effect of depression versus distress. Distress is mainly correlated with alpha 2, beta 1 and beta 2 activity of the right frontopolar cortex and orbitofrontal cortex in combination with beta 2 activation of the anterior cingulate cortex. In contrast, the more permanent depressive alterations induced by tinnitus are associated with activity of alpha 2 activity in the left frontopolar and orbitofrontal cortex. These specific neural circuits are embedded in a greater neural network, with the parahippocampal region functioning as a crucial linkage between both tinnitus related pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.