SynthesisPloS one2012
Impact of genetic notification on smoking cessation: systematic review and pooled-analysis.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Can Communicating Personalised Disease Risk Promote Healthy Behaviour Change? A Systematic Review of Systematic Reviews.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2017Pooled it
- The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis.BMJ (Clinical research ed.) · 2016Pooled it
- Feasibility of precision smoking treatment in a low-income community setting: results of a pilot randomized controlled trial in The Southern Community Cohort Study.Addiction science & clinical practice · 2024Trial
- Returning complex genetic risk information to promote better health-related behaviors: a commentary of the literature and suggested next steps.Translational behavioral medicine · 2023Article
- Dispositional optimism and optimistic bias: Associations with cessation motivation, confidence, and attitudes.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2022Article
- Attitudes toward Precision Treatment of Smoking in the Southern Community Cohort Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Learning one's genetic risk changes physiology independent of actual genetic risk.Nature human behaviour · 2019Article
- Most Current Smokers Desire Genetic Susceptibility Testing and Genetically-Efficacious Medication.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2018Observational
- Implications of Personal Genomic Testing for Health Behaviors: The Case of Smoking.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Article
- A preliminary exploration of college smokers' reactions to nicotine dependence genetic susceptibility feedback.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2015Article
- How could disclosing incidental information from whole-genome sequencing affect patient behavior?Personalized medicine · 2013Article
- Communicating genetic risk information for common disorders in the era of genomic medicine.Annual review of genomics and human genetics · 2013Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to evaluate the impact of genetic notification of smoking-related disease risk on smoking cessation in the general population. Secondary objectives were to assess the impact of genetic notification on intention-to-quit smoking and on emotional outcomes as well as the understanding and the recall of this notification.
methodsA systematic review of articles from inception to August 2011 without language restriction was realized using PubMed, Embase, Scopus, Web of Science, PsycINFO and Toxnet. Other publications were identified using hand search. The pooled-analysis included only randomized trials. Comparison groups were (i) high and low genetic risk versus control, and (ii) high versus low genetic risk. For the pooled-analysis random effect models were applied and sensitivity analyses were conducted.
resultsEight papers from seven different studies met the inclusion criteria of the review. High genetic risk notification was associated with short-term increased depression and anxiety. Four randomized studies were included in the pooled-analysis, which revealed a significant impact of genetic notification on smoking cessation in comparison to controls (clinical risk notification or no intervention) in short term follow-up less than 6 months (RR = 1.55, 95% CI 1.09-2.21).
conclusionsIn short term follow-up, genetic notification increased smoking cessation in comparison to control interventions. However, there is no evidence of long term effect (up to 12 month) on smoking cessation. Further research is needed to assess more in depth how genetic notification of smoking-related disease could contribute to smoking cessation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.