ArticlePloS one2012
The association of 25-hydroxyvitamin D3 and D2 with behavioural problems in childhood.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review.Nutrients · 2021Pooled it
- Vitamin D Status and Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis of Observational Studies.Advances in nutrition (Bethesda, Md.) · 2018Pooled it
- Clinical and metabolic response to vitamin D plus probiotic in schizophrenia patients.BMC psychiatry · 2019Trial
- Effect of vitamin D treatment in children with attention-deficit hyperactivity disorder.World journal of pediatrics : WJP · 2019Trial
- Vitamin D in Central Nervous System: Implications for Neurological Disorders.International journal of molecular sciences · 2024Review
- Comparison of serum vitamin D levels between healthy and ADHD children.Caspian journal of internal medicine · 2023Article
- Nutritional factors associated with aggression.Frontiers in psychiatry · 2023Review
- Vitamin D level in relation to depression symptoms during adolescence.Child and adolescent psychiatry and mental health · 2022Article
- Associations between mental health competence and indicators of physical health and cognitive development in eleven year olds: findings from the UK Millennium Cohort Study.BMC public health · 2019Article
- Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh.PloS one · 2019Observational
- Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians.Italian journal of pediatrics · 2018Review
- Vitamin D and mental health in children and adolescents.European child & adolescent psychiatry · 2017Review
- Low 25(OH)-vitamin D concentrations are associated with emotional and behavioral problems in German children and adolescents.PloS one · 2017Article
- Association of circulating 25-hydroxyvitamin D with mental well-being in a population-based, nationally representative sample of German adolescents.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
- The Relationship between Serum Vitamin D Level and Attention Deficit Hyperactivity Disorder.Iranian journal of child neurology · 2015Article
- Vitamin D Status at Birth and Future Risk of Attention Deficit/Hyperactivity Disorder (ADHD).PloS one · 2015Article
- A Framework for Intentional Cultural Change.Journal of contextual behavioral science · 2013Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundHigher serum concentrations of 25-hydroxyvitamin D (25(OH)D), an indicator of vitamin D synthesis and intake, have been associated with better mental health and cognitive function. Concentrations of 1,25-dihydroxyvitamin D(3) (the active vitamin D(3) metabolite) have been associated with openness and extrovert behaviour, but 25(OH)D concentrations have not been associated with behavioural problems in humans.
methodsWe investigated the prospective association between the different forms of 25(OH)D - 25(OH)D(3) and 25(OH)D(2)- and childhood behavioural problems in Avon Longitudinal Study of Parents and Children (ALSPAC). Serum 25(OH)D(3) and 25(OH)D(2) concentrations were assessed at mean age 9.9 years. Incident behavioural problems were assessed with Strengths and Difficulties Questionnaire (SDQ; emotional symptoms, conduct problems, hyperactivity-inattention problems, peer relationship problems and pro-social behaviour subscales and total difficulties score) at mean age 11.7. Sample sizes varied between 2413-2666 depending on the outcome.
resultsHigher 25(OH)D(3) concentrations were weakly associated with lower risk of prosocial problems (fully adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.74, 0.98)). Serum 25(OH)D(3) or 25(OH)D(2) concentrations were not associated with other subscales of SDQ or total difficulties score after adjusting for concfounders and other measured analytes related to vitamin D.
conclusionsOur findings do not support the hypothesis that 25-hydroxyvitamin D status in childhood has important influences on behavioural traits in humans.
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