ArticlePloS one2012
Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 79 citations in OpenAlex.
- Magnetoencephalography Reveals a Widespread Increase in Network Connectivity in Idiopathic/Genetic Generalized Epilepsy.PloS one · 2015Trial
- Altered neurovascular coupling in children with idiopathic generalized epilepsy.CNS neuroscience & therapeutics · 2023Article
- Abnormal static and dynamic functional network connectivity of the whole-brain in children with generalized tonic-clonic seizures.Frontiers in neuroscience · 2023Article
- Effect of frequency and rhythmicity on flicker light-induced hallucinatory phenomena.PloS one · 2023Article
- Pathway-specific inhibition of critical projections from the mediodorsal thalamus to the frontal cortex controls kindled seizures.Progress in neurobiology · 2022Article
- Multimodal connectome biomarkers of cognitive and affective dysfunction in the common epilepsies.Network neuroscience (Cambridge, Mass.) · 2022Article
- Reconfiguration of static and dynamic thalamo-cortical network functional connectivity of epileptic children with generalized tonic-clonic seizures.Frontiers in neuroscience · 2022Article
- Neuroimaging in the Epileptic Baboon.Frontiers in veterinary science · 2022Review
- Probabilistic mapping of thalamic nuclei and thalamocortical functional connectivity in idiopathic generalised epilepsy.Human brain mapping · 2021Article
- Cortico-striato-thalamo-cerebellar networks of structural covariance underlying different epilepsy syndromes associated with generalized tonic-clonic seizures.Human brain mapping · 2021Article
- Disrupted topological properties of functional networks in epileptic children with generalized tonic-clonic seizures.Brain and behavior · 2020Article
- Impaired Topological Properties of Gray Matter Structural Covariance Network in Epilepsy Children With Generalized Tonic-Clonic Seizures: A Graph Theoretical Analysis.Frontiers in neurology · 2020Article
- Frequency-Dependent Changes in Interhemispheric Functional Connectivity Measured by Resting-State fMRI in Children With Idiopathic Generalized Epilepsy.Frontiers in neurology · 2020Article
- Community-informed connectomics of the thalamocortical system in generalized epilepsy.Neurology · 2019Article
- Neuroimaging of Sudden Unexpected Death in Epilepsy (SUDEP): Insights From Structural and Resting-State Functional MRI Studies.Frontiers in neurology · 2019Review
- Multimodal Data and Machine Learning for Detecting Specific Biomarkers in Pediatric Epilepsy Patients With Generalized Tonic-Clonic Seizures.Frontiers in neurology · 2018Article
- Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures.NeuroImage. Clinical · 2017Article
- Disrupted structural and functional rich club organization of the brain connectome in patients with generalized tonic-clonic seizure.Human brain mapping · 2016Article
- Voxel-based morphometry in epileptic baboons: Parallels to human juvenile myoclonic epilepsy.Epilepsy research · 2016Article
- Aberrant long-range functional connectivity density in generalized tonic-clonic seizures.Medicine · 2016Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNeuroimaging evidence suggested that the thalamic nuclei may play different roles in the progress of idiopathic generalized epilepsy (IGE). This study aimed to demonstrate the alterations in morphometry and functional connectivity in the thalamic nuclei in IGE.
methodsFifty-two patients with IGE characterized by generalized tonic-clonic seizures and 67 healthy controls were involved in the study. The three-dimensional high-resolution T1-weighted MRI data were acquired for voxel-based morphometry (VBM) analysis, and resting-state blood-oxygenation level functional MRI data were acquired for functional connectivity analysis. The thalamic nuclei of bilateral medial dorsal nucleus (MDN) and pulvinar, as detected with decreased gray matter volumes in patients with IGE through VBM analysis, were selected as seed regions for functional connectivity analysis.
resultsDifferent alteration patterns were found in functional connectivity of the thalamic nuclei with decreased gray matter volumes in IGE. Seeding at the MDN, decreased connectivity in the bilateral orbital frontal cortex, caudate nucleus, putamen and amygdala were found in the patients (P<0.05 with correction). However, seeding at the pulvinar, no significant alteration of functional connectivity was found in the patients (P<0.05 with correction).
conclusionsSome specific impairment of thalamic nuclei in IGE was identified using morphological and functional connectivity MRI approaches. These findings may strongly support the different involvement of the thalamocortical networks in IGE.
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