ArticlePloS one2012
Characteristic gene selection via weighting principal components by singular values.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A P-Norm Robust Feature Extraction Method for Identifying Differentially Expressed Genes.PloS one · 2015Article
- A class-information-based penalized matrix decomposition for identifying plants core genes responding to abiotic stresses.PloS one · 2014Article
- Robust PCA based method for discovering differentially expressed genes.BMC bioinformatics · 2013Article
- Applications of Bayesian gene selection and classification with mixtures of generalized singular g-priors.Computational and mathematical methods in medicine · 2013Article
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5 authors.
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Abstract
Conventional gene selection methods based on principal component analysis (PCA) use only the first principal component (PC) of PCA or sparse PCA to select characteristic genes. These methods indeed assume that the first PC plays a dominant role in gene selection. However, in a number of cases this assumption is not satisfied, so the conventional PCA-based methods usually provide poor selection results. In order to improve the performance of the PCA-based gene selection method, we put forward the gene selection method via weighting PCs by singular values (WPCS). Because different PCs have different importance, the singular values are exploited as the weights to represent the influence on gene selection of different PCs. The ROC curves and AUC statistics on artificial data show that our method outperforms the state-of-the-art methods. Moreover, experimental results on real gene expression data sets show that our method can extract more characteristic genes in response to abiotic stresses than conventional gene selection methods.
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