ArticleOncology letters2012
Identification of multiple pathways involved in the malignant transformation of endometriosis (Review).
Article in Oncology letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01809561 (Telomeres Evaluation in Endometriosis), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Telomeres Evaluation in Endometriosis
Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Natural Products Targeting Oxidative Stress-Inflammation Crosstalk in Endometriosis.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Malignant transformation of abdominal wall endometriosis: a case report and literature review.Gynecology and pelvic medicine · 2026Article
- Exploring the Shared Pathogenesis Mechanisms of Endometriosis and Cancer: Stemness and Targeted Treatments of Its Molecular Pathways-A Narrative Review.International journal of molecular sciences · 2024Review
- Endometriosis, a common but enigmatic disease with many faces: current concept of pathophysiology, and diagnostic strategy.Japanese journal of radiology · 2024Review
- New Insights into Genetics of Endometriosis-A Comprehensive Literature Review.Diagnostics (Basel, Switzerland) · 2023Review
- Adenomyosis and Its Possible Malignancy: A Review of the Literature.Diagnostics (Basel, Switzerland) · 2023Review
- Diagnosis and treatment of tubal endometriosis in women undergoing laparoscopy: A case series from a single hospital.World journal of clinical cases · 2022Article
- Disseminated Endometriosis and Low-Grade Endometrioid Stromal Sarcoma in a Patient with a History of Uterine Morcellation for Adenomyosis.Case reports in obstetrics and gynecology · 2020Article
- Article
- ADAM9 is over-expressed in human ovarian clear cell carcinomas and suppresses cisplatin-induced cell death.Cancer science · 2018Article
- A Single-Centre Experience on the Management of Adenosarcoma: A Successful Report of an Integrated Medical and Surgical Approach.Clinical Medicine Insights. Oncology · 2018Article
- Morphological and immunohistochemical characterization of spontaneous endometriosis in rhesus macaques (Primate biology · 2017Article
- Uterine Adenosarcoma: a Review.Current oncology reports · 2016Review
- Cyst fluid hemoglobin species in endometriosis and its malignant transformation: The role of metallobiology.Oncology letters · 2016Article
- Oxidative Stress and Antioxidant Defense in Endometriosis and Its Malignant Transformation.Oxidative medicine and cellular longevity · 2015Review
- MicroRNA-21 is a candidate driver gene for 17q23-25 amplification in ovarian clear cell carcinoma.BMC cancer · 2014Article
- Müllerian adenosarcoma arising from rectal endometriosis.Annals of coloproctology · 2014Article
- [Endometriosis-related ovarian tumors].Der Pathologe · 2014Review
- Women with endometriosis have a higher DNA repair capacity and diminished breast cancer risk.Molecular cancer biology · 2013Article
- Toward an understanding of the pathophysiology of clear cell carcinoma of the ovary (Review).Oncology letters · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between endometriosis and malignant transformation has often been described in the medical literature. A search was conducted between 1966 and 2010 through the English language literature (online Medline PubMed database) using the keywords endometriosis combined with malignant transformation. The search revealed an increase in reports describing endometriosis and malignancy. Approximately 1.0% of women with endometriosis have lesions that undergo malignant transformation. The malignant processes that are associated with endometriosis may be classified into three groups: i) epithelial ovarian cancers (endometrioid adenocarcinoma and clear cell carcinoma), ii) other Müllerian-type tumors, including Müllerian-type mucinous borderline tumor and serous borderline tumor and iii) sarcomas such as adenosarcoma and endometrial stromal sarcoma in the female pelvic cavity. Persistent oxidative stress induced by endometriosis-dependent hemorrhage may be associated with carcinogenesis. In conclusion, the malignant transformation of endometriosis has multiple pathways of development and may share a common pathogenic mechanism; iron-induced oxidative stress derived from repeated hemorrhage.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.