ArticlePLoS genetics2012
Functional evolution of mammalian odorant receptors.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.
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Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it, 205 citations in OpenAlex.
- Microbial volatile organic compounds and olfactory receptors in wound malodor.Frontiers in cellular and infection microbiology · 2026Pooled it
- Sensomics-based characterization of cinnamon-like aroma inFood chemistry: X · 2026Article
- Theoretical study for investigating three experimental dose-response curves of rosy odorants on human olfactory receptor OR2A25 via molecular docking calculations and statistical physics modeling.Journal of computer-aided molecular design · 2026Article
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Elucidating odorant synergy in red wine: through olfactory receptor-based profiling.NPJ science of food · 2026Article
- Premature aging of red wines: a matter of fatty acid oxidation? A review on lipid-derived molecular markers and their possible precursors.Journal of the science of food and agriculture · 2025Review
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.bioRxiv : the preprint server for biology · 2025Article
- Potential role of terpenes in recovery from olfactory dysfunction with olfactory training: a review.Molecular biology reports · 2025Review
- Understanding the adsorption mechanism of geosmin, linalool, and o-cresol on Machilis hrabei olfactory receptor MhOR5 via statistical physics modeling and molecular docking simulation.Journal of molecular modeling · 2025Article
- Harnessing Odorant Receptor Activation to Suppress Real Malodor.International journal of molecular sciences · 2025Article
- Attraction and aversion of noctuid moths to fermented food sources coordinated by olfactory receptors from distinct gene families.BMC biology · 2025Article
- Targeting Odorant Receptors in Adipose Tissue with Food-Derived Odorants: A Novel Approach to Obesity Treatment.Foods (Basel, Switzerland) · 2024Review
- Conserved pattern-based classification of human odorant receptor multigene family.Scientific reports · 2024Article
- Evolution of Sensory Receptors.Annual review of cell and developmental biology · 2024Review
- Geosmin, a Food- and Water-Deteriorating Sesquiterpenoid and Ambivalent Semiochemical, Activates Evolutionary Conserved Receptor OR11A1.Journal of agricultural and food chemistry · 2024Article
- An evolutionarily conserved olfactory receptor is required for sex differences in blood pressure.Science advances · 2024Article
- Petrol Note in Riesling - 1,1,6-Trimethyl-1,2-dihydronaphthalene (TDN) Selectively Activates Human Odorant Receptor OR8H1.Journal of agricultural and food chemistry · 2024Article
- Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes.Physiological reviews · 2023Review
- Antagonistic interactions between odorants alter human odor perception.Current biology : CB · 2023Article
- Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1.Journal of chemical information and modeling · 2023Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The mammalian odorant receptor (OR) repertoire is an attractive model to study evolution, because ORs have been subjected to rapid evolution between species, presumably caused by changes of the olfactory system to adapt to the environment. However, functional assessment of ORs in related species remains largely untested. Here we investigated the functional properties of primate and rodent ORs to determine how well evolutionary distance predicts functional characteristics. Using human and mouse ORs with previously identified ligands, we cloned 18 OR orthologs from chimpanzee and rhesus macaque and 17 mouse-rat orthologous pairs that are broadly representative of the OR repertoire. We functionally characterized the in vitro responses of ORs to a wide panel of odors and found similar ligand selectivity but dramatic differences in response magnitude. 87% of human-primate orthologs and 94% of mouse-rat orthologs showed differences in receptor potency (EC50) and/or efficacy (dynamic range) to an individual ligand. Notably dN/dS ratio, an indication of selective pressure during evolution, does not predict functional similarities between orthologs. Additionally, we found that orthologs responded to a common ligand 82% of the time, while human OR paralogs of the same subfamily responded to the common ligand only 33% of the time. Our results suggest that, while OR orthologs tend to show conserved ligand selectivity, their potency and/or efficacy dynamically change during evolution, even in closely related species. These functional changes in orthologs provide a platform for examining how the evolution of ORs can meet species-specific demands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.