ArticleWorld journal of gastroenterology2012
Anticoagulation therapy prevents portal-splenic vein thrombosis after splenectomy with gastroesophageal devascularization.
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Splanchnic Vein Thrombosis in Liver Cirrhosis After Splenectomy or Splenic Artery Embolization: A Systematic Review and Meta-Analysis.Advances in therapy · 2021Pooled it
- Low-molecular weight heparin prevents portal vein system thrombosis after splenectomy: a systematic review and meta-analysis.ANZ journal of surgery · 2020Pooled it
- [Clinical effect of low-molecular-weight heparin in prevention and treatment of liver cirrhosis and portal vein thrombosis after splenectomy: a systematic review and meta-analysis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2016Pooled it
- Techniques of TIPS in the treatment of liver cirrhosis combined with incompletely occlusive main portal vein thrombosis.Scientific reports · 2016Trial
- Portal vein velocity predicts portal vein system thrombosis after splenectomy with esophagogastric devascularization.Surgical endoscopy · 2024Article
- Early prevention and risk factors analysis of portal vein system thrombosis after laparoscopic splenectomy and pericardial devascularization.Surgical endoscopy · 2022Article
- Evaluation of the risk factors for venous thromboembolism post splenectomy - A ten year retrospective cohort study in St James's hospital.Annals of medicine and surgery (2012) · 2021Article
- Article
- A novel method detecting the key clinic factors of portal vein system thrombosis of splenectomy & cardia devascularization patients for cirrhosis & portal hypertension.BMC bioinformatics · 2019Article
- Effect of low-dose aspirin administration on long-term survival of cirrhotic patients after splenectomy: A retrospective single-center study.World journal of gastroenterology · 2019Article
- Acute portal vein thrombosis after hepatectomy in a patient with hepatolithiasis: A case report and review of the literature.Medicine · 2018Article
- The Best Anticoagulation Strategy for Cirrhotic Patients who Underwent Splenectomy: A Network Meta-Analysis.Gastroenterology research and practice · 2017Review
- Hassab's operation for Joubert syndrome with congenital hepatic fibrosis: A case report.International journal of surgery case reports · 2017Article
- Early prophylactic anticoagulation for portal vein system thrombosis after splenectomy: A systematic review and meta-analysis.Biomedical reports · 2016Article
- Resveratrol Reduces the Incidence of Portal Vein System Thrombosis after Splenectomy in a Rat Fibrosis Model.Oxidative medicine and cellular longevity · 2016Article
- A comparative study of two anti-coagulation plans on the prevention of PVST after laparoscopic splenectomy and esophagogastric devascularization.Journal of thrombosis and thrombolysis · 2015Article
- Long-term efficacy of subtotal splenectomy due to portal hypertension in cirrhotic patients.BMC surgery · 2015Article
- Changing common sense: Anti-platelet/coagulation therapy against cirrhosis.World journal of hepatology · 2015Article
- Pharmacologic prophylaxis of portal venous system thrombosis after splenectomy: a meta-analysis.Gastroenterology research and practice · 2014Review
- Prognosis of patients with hepatocellular carcinoma and hypersplenism after surgery: a single-center experience from the People's Republic of China.OncoTargets and therapy · 2014Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo compare the incidence of early portal or splenic vein thrombosis (PSVT) in patients treated with irregular and regular anticoagulantion after splenectomy with gastroesophageal devascularization.
methodsWe retrospectively analyzed 301 patients who underwent splenectomy with gastroesophageal devascularization for portal hypertension due to cirrhosis between April 2004 and July 2010. Patients were categorized into group A with irregular anticoagulation and group B with regular anticoagulation, respectively. Group A (153 patients) received anticoagulant monotherapy for an undesignated time period or with aspirin or warfarin without low-molecular-weight heparin (LMWH) irregularly. Group B (148 patients) received subcutaneous injection of LMWH routinely within the first 5 d after surgery, followed by oral warfarin and aspirin for one month regularly. The target prothrombin time/international normalized ratio (PT/INR) was 1.25-1.50. Platelet and PT/INR were monitored. Color Doppler imaging was performed to monitor PSVT as well as the effectiveness of thrombolytic therapy.
resultsThe patients' data were collected and analyzed retrospectively. Among the patients, 94 developed early postoperative mural PSVT, including 63 patients in group A (63/153, 41.17%) and 31 patients in group B (31/148, 20.94%). There were 50 (32.67%) patients in group A and 27 (18.24%) in group B with mural PSVT in the main trunk of portal vein. After the administration of thrombolytic, anticoagulant and anti-aggregation therapy, complete or partial thrombus dissolution achieved in 50 (79.37%) in group A and 26 (83.87%) in group B.
conclusionRegular anticoagulation therapy can reduce the incidence of PSVT in patients who undergo splenectomy with gastroesophageal devascularization, and regular anticoagulant therapy is safer and more effective than irregular anticoagulant therapy. Early and timely thrombolytic therapy is imperative and feasible for the prevention of PSVT.
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