ArticleMolecular and cellular biochemistry1990
Cardiac alpha-crystallin. II. Intracellular localization.
Article in Molecular and cellular biochemistry, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 60 citations in OpenAlex.
- Chaperone proteins protect against desmin fragment amyloid aggregation.Biophysical journal · 2026Article
- The expressions of HSP70 and αB-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs.Journal of veterinary science · 2011Article
- Interactive sequences in the stress protein and molecular chaperone human alphaB crystallin recognize and modulate the assembly of filaments.The international journal of biochemistry & cell biology · 2007Article
- Molecular characterization of Oryza sativa 16.9 kDa heat shock protein.The Biochemical journal · 1999Article
- Small heat shock protein suppression of Vpr-induced cytoskeletal defects in budding yeast.Molecular and cellular biology · 1997Article
- Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Regulation of the murine alpha B-crystallin/small heat shock protein gene in cardiac muscle.Molecular and cellular biology · 1995Article
- Kinetic changes of alpha B crystallin expression in neoplastic cells and syngeneic rat fibroblasts at various subculture stages.Molecular and cellular biochemistry · 1995Article
- alpha-Crystallins, versatile stress-proteins.Molecular biology reports · 1995Review
- Sense and antisense modification of glial alpha B-crystallin production results in alterations of stress fiber formation and thermoresistance.The Journal of cell biology · 1994Article
- Alpha B-crystallin expression in mouse NIH 3T3 fibroblasts: glucocorticoid responsiveness and involvement in thermal protection.Molecular and cellular biology · 1993Article
- Expression of the murine small heat shock proteins hsp 25 and alpha B crystallin in the absence of stress.The Journal of cell biology · 1993Article
- The twelfth Frederick H. Verhoeff Lecture: gene sharing in the visual system.Transactions of the American Ophthalmological Society · 1993Review
- A superfamily in the mammalian eye lens: the beta/gamma-crystallins.Molecular biology reports · 1992Review
- Alpha B crystallin accumulation is a specific response to Ha-ras and v-mos oncogene expression in mouse NIH 3T3 fibroblasts.Molecular and cellular biology · 1991Article
- Cardiac alpha-crystallin. III. Involvement during heart ischemia.Molecular and cellular biochemistry · 1990Article
- Determination of alpha B crystallin aggregation: a new alternative method to assess ischemic damage of the heart.Basic research in cardiologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major component of the soluble fraction of rat heart is a homopolymer (Mr about 400-650 k) of a small protein (Mr about 20 k). This cardiac protein, which is highly homologous to alpha-B-crystallin, was isolated in its native state and visualized by electron microscopy. A homogeneous population of globular particles with an average diameter of about 14-16 nM could be seen using either negative staining or rotary shadowing procedures. The structures were globular in nature with a central depression (torus-like structures). Polyclonal antibodies, raised against the cardiac crystallin, were used for the immunocytochemical localization of the macromolecular complexes. Using fluorescent secondary antibodies, a clear and sharp striation of fixed and permeabilized rat heart myocytes could be observed, similar to that observed with anti-desmin antibodies and characteristic for the central region of the I-band. Cardiac crystallin was not found associated with F-actin in preparations of rat heart myofibrils. On the other hand, it was a major contaminant of cardiac desmin preparations. These observations suggest that cardiac crystallin is involved in the organization of cytoskeletal filaments of the Z-lines.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.