ArticleThe Journal of infectious diseases2012
The effect of a structural intervention for syphilis control among 3597 female sex workers: a demonstration study in South China.
Article in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Risk behaviours among female sex workers in China: a systematic review and data synthesis.PloS one · 2015Pooled it
- Experiences of Integration of HIV, Hepatitis, and Sexually Transmitted Infection Services Across Different Countries Worldwide: A Scoping Review.Health science reports · 2026Article
- Spatiotemporal heterogeneity and multiscale social influencing factors of syphilis in the mainland of China, 2005-2022.iScience · 2026Article
- Integration of HIV, Hepatitis B, and C, and sexually transmitted infections services: A scoping review of the benefits and challenges.PloS one · 2026Article
- The changing epidemiology of syphilis: new strategies for new challenges in China.The Lancet regional health. Western Pacific · 2025Review
- Weaknesses in primary health care favor the growth of acquired syphilis.PLoS neglected tropical diseases · 2021Article
- Prevalence of syphilis in female sex workers in three countryside cities of the state of Pará, Brazilian Amazon.BMC infectious diseases · 2020Article
- A community-based comprehensive intervention to reduce syphilis infection among low-fee female sex workers in China: a matched-pair, community-based randomized study.Infectious diseases of poverty · 2019Article
- HIV prevalence among female sex workers in Guigang City, Guangxi, China: an 8-year consecutive cross-sectional study.BMC public health · 2018Article
- Exploring HIV prevention strategies among street-based female sex workers in Chongqing, China.International journal of environmental research and public health · 2015Article
- What role does transactional sex play in the HIV/STI and reproductive health risk behaviour among high-tier entertainment centre workers in China?Global public health · 2015Article
- Unpacking the 'structural' in a structural approach for HIV prevention among female sex workers: a case study from China.Global public health · 2015Article
- Screening for acute HIV infections and estimating HIV incidence among female sex workers from low-grade venues in Guangxi, China.PloS one · 2014Article
- Outreach syphilis testing services by different health providers to female sex workers in southern China.PloS one · 2013Article
- Seropositivity and risk factors for herpes simplex virus type 2 infection among female sex workers in Guangxi, China.PloS one · 2013Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundSyphilis has made a rapid resurgence in China, especially among high-risk groups including female sex workers (FSWs).
methodsTwo cities in each of 3 provinces in South China were chosen and allocated to intervention or control arms. The intervention consisted of enhancing community-based syphilis screening outreach intervention with comprehensive sexually transmitted infection services at designated clinics while the control maintained routine intervention activities. Generalized linear modeling was used to examine effect of the intervention on incident syphilis infection.
resultsA total of 8275 women were eligible, and 3597 women enrolled (n = 2011 in control arm, n = 1586 in intervention arm) in the study. The median follow-up duration was 375 days (interquartile range, 267–475). Syphilis incidence density in the intervention group was reduced by 70% (95% confidence interval, 53%–81%) compared with the incidence in the control arm. The syphilis prevention intervention benefits were robust among FSWs at low-tier venues, individuals with less than high school education, migrants, and women who did not report condom use during the last episode of sex.
conclusionsIntegrated sexually transmitted infection and human immunodeficiency virus prevention strategies substantially reduce syphilis incidence among FSWs, especially among those at low-tier venues. This intervention suggests the need for scaling up comprehensive FSW programs in China.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.