Evidence map›Paper›PMID 22807190›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2012

Cell-penetrating peptides as delivery vehicles for a protein-targeted terbium complex.

Shabnam Mohandessi, Megha Rajendran, Darren Magda, Lawrence W Miller

Open access · greenAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Transportan 10 improves the anticancer activity of cisplatin.Naunyn-Schmiedeberg's archives of pharmacology · 2016
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. How to build a time-gated luminescence microscope.Current protocols in cytometry · 2014
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Shabnam MohandessiDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Megha Rajendran
Darren Magda
Lawrence W Miller
University of Illinois Chicago · USLumiphore (United States) · US

Funding

Targeted lanthanide contrast agents for in cellulo single molecule imagingR01GM081030 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MILLER, LAWRENCE · 2008 to 2018
$2.5M
NIGMS NIH HHS R01 GM081030NIGMS NIH HHS R01GM081030-01A1
6 · The paper itself

Abstract

Release after transmission: Arginine-rich, cell-penetrating peptides (CPPs) mediate cytoplasmic delivery of trimethoprim (TMP)-terbium complex conjugates and selective, intracellular labeling of E. coli dihydrofolate reductase (eDHFR) fusion proteins. A disulfide bond linking CPP and cargo is reduced following uptake. CPP conjugation can be used to deliver otherwise cell-impermeable, ligand-fluorophore conjugates.

Indexed as

Amino Acid SequenceAnimalsArginineCell LineCell Membrane PermeabilityCell-Penetrating PeptidesDogsDrug CarriersEndocytosisEscherichia coliFluorescent DyesLuminescent ProteinsMolecular ImagingMolecular Sequence DataRecombinant Fusion ProteinsStaining and LabelingArginineCell-Penetrating PeptidesDrug CarriersFluorescent DyesLuminescent ProteinsRecombinant Fusion ProteinsTerbium

Identifiers

PMID22807190
PMCPMC3729426
OpenAlexW2141717567

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.