ArticleSynapse (New York, N.Y.)2012
Paradoxical effects of the endocannabinoid uptake inhibitor VDM11 on accumbal neural encoding of reward predictive cues.
Article in Synapse (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Endocannabinoid and dopaminergic system: the pas de deux underlying human motivation and behaviors.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Bi-directional modulation of food habit expression by the endocannabinoid system.The European journal of neuroscience · 2019Article
- The cannabinoid transporter inhibitor OMDM-2 reduces social interaction: Further evidence for transporter-mediated endocannabinoid release.Neuropharmacology · 2018Article
- Cannabinoid modulation of drug reward and the implications of marijuana legalization.Brain research · 2015Review
- Role of the endogenous cannabinoid system in nicotine addiction: novel insights.Frontiers in psychiatry · 2015Review
- Using dopamine research to generate rational cannabinoid drug policy.Drug testing and analysis · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
A growing body of evidence implicates the endocannabinoid (eCB) system in brain reward function. Previous studies show that antagonizing eCB transmission decreases reward-directed behavior and nucleus accumbens (NAc) encoding of reward predictive cues. We, therefore, hypothesized that elevating eCB levels would uniformly facilitate NAc neural encoding of reward predictive cues and reward-directed behavior. Contrary to our expectations, the eCB transport uptake inhibitor, VDM11, dose dependently decreased both measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.