Evidence map›Paper›PMID 22806980›Full record

ArticleCerebellum (London, England)2012

Ca2+ signaling in cerebellar Purkinje neurons--editorial.

Donna Gruol, Mario Manto, Duane Haines

Abstract readEditorial
In one paragraph

Article in Cerebellum (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Donna Gruol
Mario Manto
Duane Haines

Funding

Somatic Ca2+ Signaling in CNS NeuronsR01NS045339 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI GRUOL, DONNA L · 2004 to 2007
$1.4M
IL-6 Regulation of Hippocampal Synaptic FunctionR01MH083723 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI GRUOL, DONNA L · 2009 to 2010
$941k
Alcohol-Chemokine Interactions and NeurotransmissionRC1AA019261 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI GRUOL, DONNA L · 2009 to 2010
$833k
NIAAA NIH HHS RC1 AA019261NIMH NIH HHS R01 MH083723NINDS NIH HHS R01 NS045339
6 · The paper itself

Abstract

Tight regulation of calcium (Ca(2+)) dynamics is critical for all neurons. Ca(2+) is a major mediator of cellular excitability, synaptic plasticity, and regulation of transcription, amongst others. Recent years have seen major developments in terms of understanding the roles of Ca(2+) signals in the cerebellar circuitry, especially for Purkinje neurons and granule cells. The unique morphology of Purkinje neurons serves as a platform to unravel the secrets of Ca(2+) homeostasis in cerebellar microcircuits. This special issue covers recent advances in Ca(2+) signaling and imaging, and highlights the importance of spatiotemporal compartmentalization underlying Ca(2+) dynamics. Sorting out the pieces of the puzzle of homeostatic regulation of Ca(2+) remains an instrumental step to start rational therapies of Ca(2+) deregulation.

Indexed as

Action PotentialsAnimalsCalcium SignalingCerebellar CortexCerebellumHumansModels, NeurologicalNeuronsPatch-Clamp TechniquesPurkinje Cells

Identifiers

PMID22806980
PMCPMC3570272

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.