SynthesisHuman brain mapping2013
An investigation of the structural, connectional, and functional subspecialization in the human amygdala.
Synthesis in Human brain mapping, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 229 papers, 21 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
229 citing papers in PubMed, 21 syntheses or guidelines pooled it.
- Common alterations of whole and subregion-specific amygdala intrinsic functional connectivity across psychiatric disorders: a meta-analysis.Molecular psychiatry · 2026Pooled it
- Neural correlates of implicit emotion regulation in mood and anxiety disorders: an fMRI meta-analytic review.Scientific reports · 2025Pooled it
- Meta-analytic connectivity modelling of functional magnetic resonance imaging studies in autism spectrum disorders.Brain imaging and behavior · 2023Pooled it
- Brain Motor Network Changes in Parkinson's Disease: Evidence from Meta-Analytic Modeling.Movement disorders : official journal of the Movement Disorder Society · 2021Pooled it
- The neuropathology of bipolar disorder: systematic review and meta-analysis.Molecular psychiatry · 2020Pooled it
- Meta-analytic clustering dissociates brain activity and behavior profiles across reward processing paradigms.Cognitive, affective & behavioral neuroscience · 2020Pooled it
- Localised grey matter atrophy in multiple sclerosis is network-based: a coordinate-based meta-analysis.Clinical radiology · 2019Pooled it
- Dissociable meta-analytic brain networks contribute to coordinated emotional processing.Human brain mapping · 2018Pooled it
- You say 'prefrontal cortex' and I say 'anterior cingulate': meta-analysis of spatial overlap in amygdala-to-prefrontal connectivity and internalizing symptomology.Translational psychiatry · 2016Pooled it
- Structural and functional neural adaptations in obstructive sleep apnea: An activation likelihood estimation meta-analysis.Neuroscience and biobehavioral reviews · 2016Pooled it
- Co-Activation-Based Parcellation of the Lateral Prefrontal Cortex Delineates the Inferior Frontal Junction Area.Cerebral cortex (New York, N.Y. : 1991) · 2016Pooled it
- Functional Segregation of the Human Dorsomedial Prefrontal Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2016Pooled it
- Neurofunctional topography of the human hippocampus.Human brain mapping · 2015Pooled it
- Co-activation based parcellation of the human frontal pole.NeuroImage · 2015Pooled it
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- Human pulvinar functional organization and connectivity.Human brain mapping · 2015Pooled it
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- Determination of the posterior boundary of Wernicke's area based on multimodal connectivity profiles.Human brain mapping · 2015Pooled it
- Definition and characterization of an extended social-affective default network.Brain structure & function · 2015Pooled it
- Subspecialization in the human posterior medial cortex.NeuroImage · 2015Pooled it
169 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Although the amygdala complex is a brain area critical for human behavior, knowledge of its subspecialization is primarily derived from experiments in animals. We here employed methods for large-scale data mining to perform a connectivity-derived parcellation of the human amygdala based on whole-brain coactivation patterns computed for each seed voxel. Voxels within the histologically defined human amygdala were clustered into distinct groups based on their brain-wide coactivation maps. Using this approach, connectivity-based parcellation divided the amygdala into three distinct clusters that are highly consistent with earlier microstructural distinctions. Meta-analytic connectivity modelling then revealed the derived clusters' brain-wide connectivity patterns, while meta-data profiling allowed their functional characterization. These analyses revealed that the amygdala's laterobasal nuclei group was associated with coordinating high-level sensory input, whereas its centromedial nuclei group was linked to mediating attentional, vegetative, and motor responses. The often-neglected superficial nuclei group emerged as particularly sensitive to olfactory and probably social information processing. The results of this model-free approach support the concordance of structural, connectional, and functional organization in the human amygdala and point to the importance of acknowledging the heterogeneity of this region in neuroimaging research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.