ArticleMicrosurgery2012
Axonal regeneration and motor neuron survival after microsurgical nerve reconstruction.
Article in Microsurgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Nerve Tape Is an Effective Tool for Small Nerve Repair.Plastic and reconstructive surgery. Global open · 2025Article
- Functional assessment of local versus systemic adipose-derived stromal cell therapy in rodent peripheral nerve regeneration.Frontiers in neurology · 2025Article
- Pillar Pain After Minimally Invasive and Standard Open Carpal Tunnel Release: A Systematic Review and Meta-analysis.Journal of hand surgery global online · 2024Article
- Regenerative role of mast cells and mesenchymal stem cells in histopathology of the sciatic nerve and tibialis cranialis muscle, following denervation in rats.Iranian journal of basic medical sciences · 2024Article
- Article
- The Correlation of Sleep Disturbance and Location of Glioma Tumors: A Narrative Review.Journal of clinical medicine · 2023Review
- The Combined Use of Curcumin and Platelet-Rich Plasma Enhances Axonal Regeneration in Acute Nerve Injuries: An Experimental Study in a Rat Model.Journal of hand and microsurgery · 2023Article
- Autologous Muscle-Derived Nerve Wrap for Prevention of Symptomatic Microneuromas in Primary Nerve Repair.Cureus · 2022Article
- Article
- Laryngeal adductor function following potassium titanyl phosphate laser welding of the recurrent laryngeal nerve.The Laryngoscope · 2020Article
- Animal models used to study direct peripheral nerve repair: a systematic review.Neural regeneration research · 2020Article
- Rapid and Precise Semi-Automatic Axon Quantification in Human Peripheral Nerves.Scientific reports · 2020Article
- Proximal versus Distal Nerve Transfer for Biceps Reinnervation-A Comparative Study in a Rat's Brachial Plexus Injury Model.Plastic and reconstructive surgery. Global open · 2016Article
- A novel technique using hydrophilic polymers to promote axonal fusion.Neural regeneration research · 2016Review
- Article
- Comparison of a distal end-to-side neurorrhaphy with a proximal-distal end-to-side neurorrhaphy: in a rat model.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2015Article
- In vivo stimulation of early peripheral axon regeneration by N-propionylmannosamine in the presence of polysialyltransferase ST8SIA2.Journal of neural transmission (Vienna, Austria : 1996) · 2015Article
- Erythropoietin Attenuates the Apoptosis of Adult Neurons After Brachial Plexus Root Avulsion by Downregulating JNK Phosphorylation and c-Jun Expression and Inhibiting c-PARP Cleavage.Journal of molecular neuroscience : MN · 2015Article
- Long-term functional recovery after facial nerve transection and repair in the rat.Journal of reconstructive microsurgery · 2015Article
- Detergent-free Decellularized Nerve Grafts for Long-gap Peripheral Nerve Reconstruction.Plastic and reconstructive surgery. Global open · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Rodent models are used extensively for studying nerve regeneration, but little is known about how sprouting and pruning influence peripheral nerve fiber counts and motor neuron pools. The purpose of this study was to identify fluctuations in nerve regeneration and neuronal survival over time. One hundred and forty-four Lewis rats were randomized to end-to-end repair or nerve grafting (1.5 cm graft) after sciatic nerve transection. Quantitative histomorphometry and retrograde labeling of motor neurons were performed at 1, 3, 6, 9, 12, and 24 months and supplemented by electron microscopy. Fiber counts and motor neuron counts increased between 1 and 3 months, followed by plateau. End-to-end repair resulted in persistently higher fiber counts compared to the grafting for all time points (P < 0.05). Percent neural tissue and myelin width increased with time while fibrin debris dissipated. In conclusion, these data detail the natural history of regeneration and demonstrate that overall fiber counts may remain stable despite pruning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.