ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2013
Birth weight is more important for peak bone mineral content than for bone density: the PEAK-25 study of 1,061 young adult women.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 24 citations in OpenAlex.
- Birth weight and birth length affect future fracture risk differently in men and women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Peak Bone Mass Formation: Modern View of the Problem.Biomedicines · 2023Review
- Bone mass in Saudi women aged 20-40 years: the association with obesity and vitamin D deficiency.Archives of osteoporosis · 2022Article
- Developmental Programming of Body Composition: Update on Evidence and Mechanisms.Current diabetes reports · 2019Review
- Maternal nutrition and the developmental origins of osteoporosis in offspring: Potential mechanisms and clinical implications.Experimental biology and medicine (Maywood, N.J.) · 2018Review
- Birth size, body composition, and adrenal androgens as determinants of bone mineral density in mid-childhood.Pediatric research · 2018Article
- Recent hip fracture trends in Sweden and Denmark with age-period-cohort effects.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Effect of low birth weight on women's health.Clinical therapeutics · 2014Review
- Bone mineral density and osteoporosis after preterm birth: the role of early life factors and nutrition.International journal of endocrinology · 2013Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
unlabelledLower birth weight has a negative association with adult BMC and body composition in young adult Swedish women.
introductionThe aim of this study was to evaluate the influence of birth weight on peak bone mass and body composition in a cohort of 25-year-old women.
methodsOne thousand sixty-one women participated in this cross-sectional population-based study using dual energy X-ray absorptiometry (DXA) to assess bone mineral content (BMC), bone mineral density (BMD), and body composition (total body (TB), femoral neck (FN), total hip (TH), lumbar spine L1-L4 (LS), and lean and fat mass). Birth weight data was available for 1,047 women and was categorized into tertiles of low (≤3,180 g), intermediate (3,181-3,620 g), and high (≥3,621 g) birth weight.
resultsSignificant correlations were observed between birth weight and TB-BMC (r=0.159, p<0.001), FN-BMC (r=0.096, p<0.001), TH-BMC (r=0.102, p=0.001), LS-BMC (r=0.095, p=0.002), and lean mass (r=0.215, p<0.001). No correlation was observed between birth weight and BMD. The estimated magnitude of effect was equivalent to a 0.3-0.5 SD difference in BMC for every 1 kg difference in birth weight (151 g (TB); 0.22 g (FN); 1.5 g (TH), 2.5 kg TB lean mass). The strongest correlations between birth weight and BMC occurred in women with lowest birth weights, although excluding women who weighed<2,500 g at birth, and the correlation remained significant although slightly weaker.
conclusionsWomen with lower birth weight have lower BMC and less lean and fat mass at the age of 25, independent of current body weight. Lower birth weight has a greater negative influence on bone mass than the positive influence of higher birth weight.
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