ReviewMuscle & nerve2012
The role of sodium channels in chronic pain.
Review in Muscle & nerve, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04215757 (PERIPHERAL NERVE BLOCKS WITH LOW DOSE LIGNOCAINE FOR THE TREATMENT OF ACUTE LUMBOSACRAL RADICULOPATHY), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Peripheral nerve blocks with low dose lignocaine for the treatment of acute lumbosacral radiculopathy
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Transcutaneous electrical nerve stimulation (TENS) for neuropathic pain in adults.The Cochrane database of systematic reviews · 2017Pooled it
- Quantum Mechanical Mechanisms in the Therapeutic Effects of Spinal Cord Stimulation to Treat Chronic Neuropathic Pain: A Quantum Computational Model.Journal of pain research · 2026Article
- Reverse-engineered models reveal differential membrane properties of autonomic and cutaneous unmyelinated fibers.PLoS computational biology · 2024Article
- 2-Aminopyridines as Potent and Selective NaACS medicinal chemistry letters · 2024Article
- Sodium and water dynamics in the progression of chronic kidney disease: mechanisms and clinical significance.International urology and nephrology · 2024Review
- Effects of Nutraceutical Compositions Containing Rhizoma Gastrodiae or Lipoic Acid in an In Vitro Induced Neuropathic Pain Model.International journal of molecular sciences · 2024Article
- Pathophysiological and Neuroplastic Changes in Postamputation and Neuropathic Pain: Review of the Literature.Plastic and reconstructive surgery. Global open · 2022Article
- Mechanisms and physiological implications of cooperative gating of clustered ion channels.Physiological reviews · 2022Review
- Potential Role of Yoga Intervention in the Management of Chronic Non-malignant Pain.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Determinants of conductance of a bacterial voltage-gated sodium channel.Biophysical journal · 2021Article
- The Changes in Expression of NaMembranes · 2021Article
- Pharmacological Management of Adults with Chronic Non-Cancer Pain in General Practice.Pain and therapy · 2020Article
- Neuro-biochemical changes induced by zinc oxide nanoparticles.Saudi journal of biological sciences · 2020Article
- Conserved Expression of Nav1.7 and Nav1.8 Contribute to the Spontaneous and Thermally Evoked Excitability in IL-6 and NGF-Sensitized Adult Dorsal Root Ganglion Neurons In Vitro.Bioengineering (Basel, Switzerland) · 2020Article
- Postoperative pain pathophysiology and treatment strategies after CRS + HIPEC for peritoneal cancer.World journal of surgical oncology · 2020Review
- Supraorbital Nerve Radiofrequency for Severe Neuralgia Caused by Herpes Zoster Ophthalmicus.Pain research & management · 2020Article
- Coccydynia relieved by a tarsal tunnel block: a case series.Journal of medical case reports · 2019Article
- Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain.Medicines (Basel, Switzerland) · 2019Review
- Kinesins: Motor Proteins as Novel Target for the Treatment of Chronic Pain.Molecular neurobiology · 2019Review
- Human Dorsal Root Ganglia.Frontiers in cellular neuroscience · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Here we review recent research into the mechanisms of chronic pain that has focused on neuronal sodium channels, a target of classic analgesic agents. We first discuss evidence that specific sodium channel isoforms are essential for the detection and conduction of normal acutely painful stimuli from nociceptors. We then review findings that show changes in sodium channel expression and localization in chronic inflammation and nerve injury in animal and human tissues. We conclude by discussing the role that myelination plays in organizing and maintaining sodium channel clusters at nodes of Ranvier in normal development and how inflammatory processes or nerve injury alter the characteristics of such clusters. Based on these findings, we suggest that chronic pain may in part result from partial demyelination of axons during chronic injury, which creates aberrant sodium channel clusters that serve as sites of ectopic sensitivity or spontaneous activity.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.