ArticleArthritis and rheumatism2012
The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy.
Article in Arthritis and rheumatism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Muscle Vasculitis: A Novel Delineation of Distinct Subsets of Disease.ACR open rheumatology · 2025Article
- Skeletal muscle disorders as risk factors for type 2 diabetes.Molecular and cellular endocrinology · 2025Review
- A window into intracellular events in myositis through subcellular proteomics.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- IFNγ causes mitochondrial dysfunction and oxidative stress in myositis.Nature communications · 2024Article
- The Role of Exercise to Improve Physiological, Physical and Psychological Health Outcome in Idiopathic Inflammatory Myopathies (IIM).Journal of inflammation research · 2024Review
- Antigen-driven T cell-macrophage interactions mediate the interface between innate and adaptive immunity in histidyl-tRNA synthetase-induced myositis.Frontiers in immunology · 2023Article
- Major histocompatibility complex I-induced endoplasmic reticulum stress mediates the secretion of pro-inflammatory muscle-derived cytokines.Journal of cellular and molecular medicine · 2022Article
- Improved skeletal muscle fatigue resistance in experimental autoimmune myositis mice following high-intensity interval training.Arthritis research & therapy · 2022Article
- Secondary myoadenylate deaminase deficiency is not a common feature of inflammatory myopathies: A descriptive study.Frontiers in medicine · 2022Article
- NMR-based serum and muscle metabolomics for diagnosis and activity assessment in idiopathic inflammatory myopathies.Analytical science advances · 2021Article
- Myostatin and markers of bone metabolism in dermatomyositis.BMC musculoskeletal disorders · 2021Article
- Skeletal muscle: A review of molecular structure and function, in health and disease.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Role of Myokines in Myositis Pathogenesis and Their Potential to be New Therapeutic Targets in Idiopathic Inflammatory Myopathies.Journal of immunology research · 2020Review
- Signatures of selection and environmental adaptation across the goat genome post-domestication.Genetics, selection, evolution : GSE · 2018Article
- Transcriptional profiling identifies differential expression of long non-coding RNAs in Jo-1 associated and inclusion body myositis.Scientific reports · 2017Article
- Functional decline at the aging neuromuscular junction is associated with altered laminin-α4 expression.Aging · 2017Article
- AMPD3 is associated with the malignant characteristics of gastrointestinal stromal tumors.Oncology letters · 2017Article
- Co-expression Network Approach Reveals Functional Similarities among Diseases Affecting Human Skeletal Muscle.Frontiers in physiology · 2017Article
- Comparative Transcriptomic Study of Muscle Provides New Insights into the Growth Superiority of a Novel Grouper Hybrid.PloS one · 2016Article
- Diagnostic Algorithm for Glycogenoses and Myoadenylate Deaminase Deficiency Based on Exercise Testing Parameters: A Prospective Study.PloS one · 2015Observational
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveIt is generally believed that muscle weakness in patients with polymyositis and dermatomyositis is due to autoimmune and inflammatory processes. However, it has been observed that there is a poor correlation between the suppression of inflammation and a recovery of muscle function in these patients. This study was undertaken to examine whether nonimmune mechanisms also contribute to muscle weakness. In particular, it has been suggested that an acquired deficiency of AMP deaminase 1 (AMPD1) may be responsible for muscle weakness in myositis.
methodsWe performed comprehensive functional, behavioral, histologic, molecular, enzymatic, and metabolic assessments before and after the onset of inflammation in a class I major histocompatibility complex (MHC)-transgenic mouse model of autoimmune inflammatory myositis.
resultsMuscle weakness and metabolic disturbances were detectable in the mice prior to the appearance of infiltrating mononuclear cells. Force contraction analysis of muscle function revealed that weakness was correlated with AMPD1 expression and was myositis specific. Decreasing AMPD1 expression resulted in decreased muscle strength in healthy mice. Fiber typing suggested that fast-twitch muscles were converted to slow-twitch muscles as myositis progressed, and microarray results indicated that AMPD1 and other purine nucleotide pathway genes were suppressed, along with genes essential to glycolysis.
conclusionThese data suggest that an AMPD1 deficiency is acquired prior to overt muscle inflammation and is responsible, at least in part, for the muscle weakness that occurs in the mouse model of myositis. AMPD1 is therefore a potential therapeutic target in myositis.
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