ArticleJournal of cancer research and clinical oncology2012
Expression of MMP-9 and WAVE3 in colorectal cancer and its relationship to clinicopathological features.
Article in Journal of cancer research and clinical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Prognostic value of matrix metalloproteinase-2 protein and matrix metalloproteinase-9 protein in colorectal cancer: a meta-analysis.BMC cancer · 2024Pooled it
- Matrix metalloproteinase 9 expression and prognosis in colorectal cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Ferroptosis-like cell death induced by Amomi Fructus phenolic compounds in SGC7901 gastric cancer cells: a network pharmacology and experimental validation study.BMC complementary medicine and therapies · 2026Article
- WAVE3 Facilitates the Tumorigenesis and Metastasis of Tongue Squamous Cell Carcinoma via EMT.Applied biochemistry and biotechnology · 2024Article
- Article
- WAVE3 promotes proliferation, migration and invasion via the AKT pathway in pancreatic cancer.International journal of oncology · 2018Article
- High WAVE3 expression correlates with proliferation, migration and invasion in human ovarian cancer.Oncotarget · 2017Article
- Article
- PTK7 overexpression in colorectal tumors: Clinicopathological correlation and prognosis relevance.Oncology reports · 2016Article
- Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification.Biomicrofluidics · 2016Article
- WAVE3 Induces EMT and Promotes Migration and Invasion in Intrahepatic Cholangiocarcinoma.Digestive diseases and sciences · 2016Article
- MiR-625-3p promotes cell migration and invasion via inhibition of SCAI in colorectal carcinoma cells.Oncotarget · 2015Article
- Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma.Nature genetics · 2015Article
- Serum endostatin levels are elevated in colorectal cancer and correlate with invasion and systemic inflammatory markers.British journal of cancer · 2014Article
- Expression of WASF3 in patients with non-small cell lung cancer: Correlation with clinicopathological features and prognosis.Oncology letters · 2014Article
- Article
- Single cells from human primary colorectal tumors exhibit polyfunctional heterogeneity in secretions of ELR+ CXC chemokines.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- p42.3: a promising biomarker for the progression and prognosis of human colorectal cancer.Journal of cancer research and clinical oncology · 2013Article
- Surfing the big WAVE: Insights into the role of WAVE3 as a driving force in cancer progression and metastasis.Seminars in cell & developmental biology · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate matrix metalloproteinase 9 (MMP-9) and WAVE3 expression in human colorectal cancer (CRC) and to evaluate their clinical significance.
methodsWe first performed real-time PCR to evaluate mRNA expression of MMP-9 and WAVE3 in 21 pairs of fresh CRC samples matched with adjacent normal mucosa. Then, MMP-9 and WAVE3 proteins were evaluated by immunohistochemistry on CRC tissue microarrays which included 216 CRC specimens and corresponding normal colorectal mucosa, and their correlation with clinicopathological factors and overall survival after surgery was evaluated.
resultsBoth real-time PCR and immunohistochemistry evaluation have demonstrated that MMP-9 and WAVE3 were over-expressed in colorectal cancer tissues compared with normal mucosa (p < 0.001). MMP-9 expression was significantly higher in patients with low-grade differentiation and distant metastasis (p = 0.003 and p = 0.005, respectively), and patients with MMP-9-positive expression had a poorer prognosis (p = 0.008). However, patients with WAVE3-positive expression had a better prognosis (p = 0.039) and particularly favorable prognostic factors, including non-lymph node metastasis, non-distant metastasis, and early TNM stage (p = 0.029, 0.021, and 0.003, respectively). In addition, MMP-9-negative/WAVE3-positive patients had the best overall survival (p = 0.021). In multivariate survival analysis, MMP-9 expression and combined expression status of MMP-9/WAVE3 were identified as independent prognostic factors for CRC (p = 0.046 and p = 0.019, respectively).
conclusionsCombined analysis of MMP-9 and WAVE3 has a significant value for assessing prognosis of CRC patients after surgery.
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