ArticleCerebral cortex (New York, N.Y. : 1991)2013
Cortical brain morphology in young, estrogen-naive, and adolescent, estrogen-treated girls with Turner syndrome.
Article in Cerebral cortex (New York, N.Y. : 1991), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Executive Functions in Children and Adolescents with Turner Syndrome: A Systematic Review and Meta-Analysis.Neuropsychology review · 2018Pooled it
- Relationship between X chromosome mosaicism, neuroanatomy and cognitive performance in females.bioRxiv : the preprint server for biology · 2026Article
- Turner Syndrome With 45,X/46,XX Mosaicism and a Derivative X Chromosome (Xqter → Xq13?::Xp11.4 → Xqter): A Case Report.Clinical case reports · 2025Article
- Influences of RASopathies on Neuroanatomical Variation in Children.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Syndrome-Specific Neuroanatomical Phenotypes in Girls With Turner and Noonan Syndromes.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Adolescent brain development in girls with Turner syndrome.Human brain mapping · 2023Article
- Organ Abnormalities Caused by Turner Syndrome.Cells · 2023Review
- Depressive and anxiety symptoms, and neural correlates of reward and punishment anticipation in female athletes with amenorrhea.Frontiers in endocrinology · 2023Article
- Brain Development in School-Age and Adolescent Girls: Effects of Turner Syndrome, Estrogen Therapy, and Genomic Imprinting.Biological psychiatry · 2020Article
- Effects of hypogonadism on brain development during adolescence in girls with Turner syndrome.Human brain mapping · 2019Article
- X-Chromosome Insufficiency Alters Receptive Fields across the Human Early Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- PTPN11 Gain-of-Function Mutations Affect the Developing Human Brain, Memory, and Attention.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Sex differences in amygdala shape: Insights from Turner syndrome.Human brain mapping · 2016Article
- Morphological Changes of Amygdala in Turner Syndrome Patients.CNS neuroscience & therapeutics · 2016Article
- Triangulating the sexually dimorphic brain through high-resolution neuroimaging of murine sex chromosome aneuploidies.Brain structure & function · 2015Article
- Aberrant parietal cortex developmental trajectories in girls with Turner syndrome and related visual-spatial cognitive development: a preliminary study.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Brain morphology in children with 47, XYY syndrome: a voxel- and surface-based morphometric study.Genes, brain, and behavior · 2014Article
- High resolution whole brain imaging of anatomical variation in XO, XX, and XY mice.NeuroImage · 2013Article
- Genomic imprinting effects of the X chromosome on brain morphology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Chiari I Malformation Associated with Turner Syndrome.Journal of neurosciences in rural practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 4 countries.
Funding
Abstract
Turner syndrome (TS) is a genetic condition that permits direct investigation of the complex interaction among genes, hormones, behavior, and brain development. Here, we used automated segmentation and surface-based morphometry to characterize the differences in brain morphology in children (n = 30) and adolescents (n = 16) with TS relative to age- and sex-matched control groups (n = 21 and 24, respectively). Our results show that individuals with TS, young and adolescent, present widespread reduction of gray matter volume, white matter volume and surface area (SA) over both parietal and occipital cortices bilaterally, as well as enlarged amygdala. In contrast to the young cohort, adolescents with TS showed significantly larger mean cortical thickness and significantly smaller total SA compared with healthy controls. Exploratory developmental analyses suggested aberrant regional brain maturation in the parahippocampal gyrus and orbitofrontal regions from childhood to adolescence in TS. These findings show the existence of abnormal brain morphology early in development in TS, but also suggest the presence of altered neurodevelopmental trajectories in some regions, which could potentially be the consequences of estrogen deficiency, both pre- and postnatally.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.