ArticleEuropean journal of applied physiology2013
Fatigue is specific to working muscles: no cross-over with single-leg cycling in trained cyclists.
Article in European journal of applied physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Non-local Muscle Fatigue Effects on Muscle Strength, Power, and Endurance in Healthy Individuals: A Systematic Review with Meta-analysis.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Non-local Acute Passive Stretching Effects on Range of Motion in Healthy Adults: A Systematic Review with Meta-analysis.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Unilateral Quadriceps Fatigue Induces Greater Impairments of Ipsilateral versus Contralateral Elbow Flexors and Plantar Flexors Performance in Physically Active Young Adults.Journal of sports science & medicine · 2021Trial
- Metabolic and blood flow responses to single leg emphasis cycling compared to single and double leg cycling.Experimental physiology · 2026Article
- The cross-over effects of unilateral resistance exercise in trained males and females.European journal of applied physiology · 2026Article
- Enhancing Neuromuscular Conditioning in Football Players Through Single-Leg and Double-Leg Cycling: A Randomized Controlled Trial.Translational sports medicine · 2026Article
- Unilaterally Induced Quadriceps Fatigue during Sustained Submaximal Isometric Exercise Does Not Alter Contralateral Leg Extensor Performance.Journal of functional morphology and kinesiology · 2023Article
- Single-leg cycling to maintain and improve function in healthy and clinical populations.Frontiers in physiology · 2023Review
- Determining voluntary activation in synergistic muscles: a novel mechanomyographic approach.European journal of applied physiology · 2022Article
- Lack of Evidence for Crossover Fatigue with Plantar Flexor Muscles.Journal of sports science & medicine · 2022Article
- Physiological Responses to Counterweighted Single-Leg Cycling in Older Males.International journal of exercise science · 2020Article
- Mechanism of Fatigue Induced by Different Cycling Paradigms With Equivalent Dosage.Frontiers in physiology · 2020Article
- Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Is the cross-over effect of a unilateral high-intensity leg extension influenced by the sex of the participants?Biology of sex differences · 2018Article
- Superior mitochondrial adaptations in human skeletal muscle after interval compared to continuous single-leg cycling matched for total work.The Journal of physiology · 2017Article
- Non-local muscle fatigue: effects and possible mechanisms.European journal of applied physiology · 2015Review
- Effect of unilateral knee extensor fatigue on force and balance of the contralateral limb.European journal of applied physiology · 2015Article
- Effect of differing intensities of fatiguing dynamic contractions on contralateral homologous muscle performance.Journal of sports science & medicine · 2014Article
- Cardiovascular responses to counterweighted single-leg cycling: implications for rehabilitation.European journal of applied physiology · 2014Article
- Time course of the cross-over effect of fatigue on the contralateral muscle after unilateral exercise.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Fatigue induced via a maximal isometric contraction of a single limb muscle group can evoke a "cross-over" of fatigue that reduces voluntary muscle activation and maximum isometric force in the rested contralateral homologous muscle group. We asked whether a cross-over of fatigue also occurs when fatigue is induced via high-intensity endurance exercise involving a substantial muscle mass. Specifically, we used high-intensity single-leg cycling to induce fatigue and evaluated associated effects on maximum cycling power (P (max)) in the fatigued ipsilateral leg (FAT(leg)) as well as the rested contralateral leg (REST(leg)). On separate days, 12 trained cyclists performed right leg P (max) trials before and again 30 s, 3, 5, and 10 min after a cycling time trial (TT, 10 min) performed either with their right or left leg. Fatigue was estimated by comparing exercise-induced changes in P (max) and maximum handgrip isometric force (F (max)). Mean power produced during the right and left leg TTs did not differ (203 ± 8 vs. 199 ± 8 W). Compared to pre-TT, FAT(leg) P (max) was reduced by 22 ± 3 % at 30 s post-TT and remained reduced by 9 ± 2 % at 5 min post-TT (both P < 0.05). Despite considerable power loss in the FAT(leg), post-TT REST(leg) P (max) (596-603 W) did not differ from pre-TT values (596 ± 35 W). There were no alterations in handgrip F (max) (529-547 N). Our data suggest that any potential cross-over of fatigue, if present at all, was not sufficient to measurably compromise REST(leg) P (max) in trained cyclists. These results along with the lack of changes in handgrip F (max) indicate that impairments in maximal voluntary neuromuscular function were specific to working muscles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.