ArticlePediatric research2012
Sex-specific programming of hypertension in offspring of late-gestation diabetic rats.
Article in Pediatric research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Influence of gestational diabetes mellitus on the cardiovascular system and its underlying mechanisms.Frontiers in endocrinology · 2025Review
- Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia.Frontiers in nutrition · 2023Review
- Insights into the Mechanisms of Fetal Growth Restriction-Induced Programming of Hypertension.Integrated blood pressure control · 2021Review
- Maternal high-fat diet increases vascular contractility in adult offspring in a sex-dependent manner.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Sex-specific associations between prenatal antibiotics exposure and offspring's body mass index.International journal of obesity (2005) · 2020Article
- Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases.Biomolecules · 2020Review
- Epigenetic Down-Regulation of Sirt 1 via DNA Methylation and Oxidative Stress Signaling Contributes to the Gestational Diabetes Mellitus-Induced Fetal Programming of Heart Ischemia-Sensitive Phenotype in Late Life.International journal of biological sciences · 2019Article
- The effect of intrauterine growth restriction on CaPhysiological reports · 2018Article
- Programming of Vascular Dysfunction in the Intrauterine Milieu of Diabetic Pregnancies.International journal of molecular sciences · 2018Review
- Exposure to Maternal Diabetes Mellitus Causes Renal Dopamine DHypertension (Dallas, Tex. : 1979) · 2018Article
- Offspring risk of obesity in childhood, adolescence and adulthood in relation to gestational diabetes mellitus: a sex-specific association.International journal of epidemiology · 2017Article
- Transgenerational inheritance of susceptibility to diabetes-induced male subfertility.Scientific reports · 2017Article
- Sex-Specificity of Mineralocorticoid Target Gene Expression during Renal Development, and Long-Term Consequences.International journal of molecular sciences · 2017Article
- Sex-Specific Associations of Maternal Gestational Glycemia with Hormones in Umbilical Cord Blood at Delivery.American journal of perinatology · 2016Article
- Modeling the impact of growth and leptin deficits on the neuronal regulation of blood pressure.The Journal of endocrinology · 2016Review
- Recurrent hypoinsulinemic hyperglycemia in neonatal rats increases PARP-1 and NF-κB expression and leads to microglial activation in the cerebral cortex.Pediatric research · 2015Article
- Alterations in perivascular innervation function in mesenteric arteries from offspring of diabetic rats.British journal of pharmacology · 2015Article
- Fetal programming and cardiovascular pathology.Comprehensive Physiology · 2015Review
- Exposure to maternal gestational diabetes is associated with higher cardiovascular responses to stress in adolescent indians.The Journal of clinical endocrinology and metabolism · 2015Article
- Fetal hyperglycemia and a high-fat diet contribute to aberrant glucose tolerance and hematopoiesis in adult rats.Pediatric research · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe intrauterine environment strongly influences adult disease susceptibility. We used a rat model of third-trimester maternal diabetes to test the hypothesis that adult offspring exposed to hyperglycemia in utero display increased blood pressure and alterations in vascular responsiveness.
methodsDiabetes was induced by streptozotocin injection to pregnant rats on gestation day 13 (term 21 d) and partially controlled with insulin injections. Hemodynamic function was evaluated in 6-12-mo-old offspring.
resultsMale but not female offspring of diabetic mothers (ODM) had significantly increased blood pressure as compared with controls; heart rate (HR) was similar. For both sexes, HR baroreflex responses were similar as were in vivo hemodynamic responses to angiotensin II, nitric oxide synthase inhibition, and ganglionic blockade. Aortic contractility to angiotensin II was similar in the two groups. Nitric oxide synthase inhibition and the Cu/Zn superoxide dismutase inhibitor diethyldithiocarbamate, but not the superoxide dismutase-mimetic Tempol, significantly increased contractile responses to angiotensin II in controls but not ODM. Reduced nicotinamide adenine dinucleotide phosphate-stimulated superoxide production was greater in male ODM than in controls (P < 0.05).
conclusionExposure to hyperglycemia in utero results in sex-specific cardiovascular changes in adult offspring. Impaired nitric oxide-reactive oxygen species signaling may play a significant role in the hemodynamic phenotype of ODM.
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