ArticleAnnals of biomedical engineering2012
Multiscale modeling and data integration in the virtual physiological rat project.
Article in Annals of biomedical engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment.Frontiers in pharmacology · 2024Article
- From qualitative to quantitative: the state of the art and challenges for plant synthetic biology.Quantitative biology (Beijing, China) · 2023Review
- Multiscale modeling in disease.Current opinion in systems biology · 2021Article
- Hierarchical semantic composition of biosimulation models using bond graphs.PLoS computational biology · 2021Article
- Personalized whole-body models integrate metabolism, physiology, and the gut microbiome.Molecular systems biology · 2020Article
- Harmonizing semantic annotations for computational models in biology.Briefings in bioinformatics · 2019Review
- Predicting the murine enterocyte metabolic response to diets that differ in lipid and carbohydrate composition.Scientific reports · 2017Article
- Microvessel Chaste: An Open Library for Spatial Modeling of Vascularized Tissues.Biophysical journal · 2017Article
- CropsFrontiers in plant science · 2017Article
- Modular modelling with Physiome standards.The Journal of physiology · 2016Article
- Qualitative causal analyses of biosimulation models.CEUR workshop proceedings · 2016Article
- A Novel Method to Verify Multilevel Computational Models of Biological Systems Using Multiscale Spatio-Temporal Meta Model Checking.PloS one · 2016Article
- Article
- Computational analysis of the regulation of Ca(2+) dynamics in rat ventricular myocytes.Physical biology · 2015Article
- Semantics-Based Composition of Integrated Cardiomyocyte Models Motivated by Real-World Use Cases.PloS one · 2015Article
- Simulating physiological interactions in a hybrid system of mathematical models.Journal of clinical monitoring and computing · 2014Article
- A reappraisal of how to build modular, reusable models of biological systems.PLoS computational biology · 2014Article
- Arterial stiffening provides sufficient explanation for primary hypertension.PLoS computational biology · 2014Article
- Ontology of physics for biology: representing physical dependencies as a basis for biological processes.Journal of biomedical semantics · 2013Article
- Bridging the genotype-phenotype gap: what does it take?The Journal of physiology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
It has become increasingly evident that the descriptions of many complex diseases are only possible by taking into account multiple influences at different physiological scales. To do this with computational models often requires the integration of several models that have overlapping scales (genes to molecules, molecules to cells, cells to tissues). The Virtual Physiological Rat (VPR) Project, a National Institute of General Medical Sciences (NIGMS) funded National Center of Systems Biology, is tasked with mechanistically describing several complex diseases and is therefore identifying methods to facilitate the process of model integration across physiological scales. In addition, the VPR has a considerable experimental component and the resultant data must be integrated into these composite multiscale models and made available to the research community. A perspective of the current state of the art in model integration and sharing along with archiving of experimental data will be presented here in the context of multiscale physiological models. It was found that current ontological, model and data repository resources and integrative software tools are sufficient to create composite models from separate existing models and the example composite model developed here exhibits emergent behavior not predicted by the separate models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.